产品说明书
Estradiol (cypionate)
 |
同义名 : | Estradiol 17β-Cyclopentanepropionate;Estradiol Cypionate;β-Estradiol 17-cypionate;NSC 3354;Estradiol 17-Cypionate |
| CAS号 : | 313-06-4 | |
| 货号 : | A394620 | |
| 分子式 : | C26H36O3 | |
| 纯度 : | 98% | |
| 分子量 : | 396.562 | |
| MDL号 : | MFCD00056558 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 30 mg/mL(75.65 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Estradiol cypionate (ECP), a long-acting estrogen, has been used therapeutically in early postpartum (PP) dairy cows[3]. Compared with controls and in response to TP (testosterone propionate) or ECP, estrus occurred 8 to 18h earlier and was of greater intensity for ECP cows, respectively[4]. Substituting ECP (Estradiol valerate) for GnRH resulted in more cows in estrus and slightly fewer ovulating[5]. Early postpartum ECP injection increased pregnancy rates, but generally had detrimental effects on milk yields after 30 DIM (d in milk) for ECP-treated cows previously milked 4x daily, unless those cows also were treated with bST (bovine somatotropin)[6]. Use of 1 mg of ECP to induce ovulation as part of a synchrony regimen improved reproduction at first postpartum insemination in dairy cows[7]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02670785 | Vulvovaginal Atrophy ... 展开 >> Menopause Dyspareunia 收起 << | Phase 2 | Completed | - | United States, Arizona ... 展开 >> Visions Clinical Research-Tucson Tucson, Arizona, United States, 85712 United States, California Genesis Center for Clinical Research San Diego, California, United States, 92103 United States, Connecticut Coastal Connecticut Research, LLC New London, Connecticut, United States, 06320 United States, Florida Women's Medical Research Group, LLC Clearwater, Florida, United States, 33759 Radiant Research, Inc. Pinellas Park, Florida, United States, 33781 Comprehensive Clinical Trials, LLC West Palm Beach, Florida, United States, 33409 United States, Georgia Fellows Research Alliance, Inc Savannah, Georgia, United States, 31406 United States, Michigan Beyer Research Kalamazoo, Michigan, United States, 49009 United States, Nevada Office of R. Garn Mabey, M.D. Las Vegas, Nevada, United States, 89128 United States, North Carolina Carolina Women's Research and Wellness Center Durham, North Carolina, United States, 27713 Hawthorne Medical Research, Inc. Winston-Salem, North Carolina, United States, 27103 United States, Ohio Rapid Medical Research, Inc. Cleveland, Ohio, United States, 44122 Women's Health Research Columbus, Ohio, United States, 43213 United States, Pennsylvania Clinical Research of Philadelphia, LLC Philadelphia, Pennsylvania, United States, 19114 United States, South Carolina Fellows Research Alliance, Inc Bluffton, South Carolina, United States, 29910 United States, Texas Radiant Research, Inc. Dallas, Texas, United States, 75231 Radiant Research, Inc. San Antonio, Texas, United States, 78229 United States, Virginia Virginia Women's Center Richmond, Virginia, United States, 23233 United States, Washington Seattle Women's Health, Research, Gynecology Seattle, Washington, United States, 98105 North Spokane Women's Clinic Spokane, Washington, United States, 99207 收起 << |
| NCT00254189 | Ovulation | Phase 2 | Completed | - | - |
| NCT01507454 | - | Completed | - | Germany ... 展开 >> Novo Nordisk Investigational Site Mainz, Germany, 55127 收起 << | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.52mL 0.50mL 0.25mL |
12.61mL 2.52mL 1.26mL |
25.22mL 5.04mL 2.52mL |
| 参考文献 |
|---|