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首页 / 抑制剂/激动剂 / 抗感染 / Antibacterial / Erythromycin Ethylsuccinate

琥乙红霉素 /Erythromycin Ethylsuccinate {[allProObj[0].p_purity_real_show]}

货号：A453784 同义名： EES

Erythromycin ethylsuccinate is an antibiotic useful for the treatment of a number of bacterial infections, has an antimicrobial spectrum similar to or slightly wider than that of penicillin.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
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Erythromycin Ethylsuccinate 化学结构 CAS号：1264-62-6
Erythromycin Ethylsuccinate 化学结构
CAS号：1264-62-6
Erythromycin Ethylsuccinate 3D分子结构
CAS号：1264-62-6
Erythromycin Ethylsuccinate 化学结构 CAS号：1264-62-6
Erythromycin Ethylsuccinate 3D分子结构 CAS号：1264-62-6
规格 价格 会员价 库存 数量
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Erythromycin Ethylsuccinate 纯度/质量文件 产品仅供科研

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Erythromycin Ethylsuccinate 生物活性

描述 Erythromycin (Ethylsuccinate) is a very safe antibiotic that is effective against a wide variety of common and uncommon bacterial infections. The most common side effect of erythromycin is gastrointestinal intolerance, which appears to be related to disruption of intestinal motility[3]. Erythromycin ethylsuccinate appears to be poorly absorbed after oral administration to fasted foals. Plasma concentrations of erythromycin A remained below 0.25 microg/ml (reported minimum inhibitory concentration for Rhodococcus equi) for less than 4 hours after intragastric administration of erythromycin ethylsuccinate, suggesting that the recommended dosage (25 mg/kg every 6 hours) would be suboptimal for treatment of R. equi infections[4]. Low dosages of erythromycin ethylsuccinate can induce severe colitis in horses associated with major changes of the intestinal microflora. Clostridium difficile has been demonstrated as a potential aetiological agent in antibiotic-induced acute colitis[5]. In addition, Erythromycin ethylsuccinate has antiviral activity against HIV-1[6].

Erythromycin Ethylsuccinate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02215967 Myeloma, Plasma-Cell ... 展开 >> Myeloma-Multiple 收起 << Phase 1 Active, not recruiting October 31, 2019 United States, Maryland ... 展开 >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 收起 <<
NCT02775968 - Recruiting October 2022 China ... 展开 >> Beijing Children's Hospital of Capital Medical University Recruiting Beijing, China Contact: Adong Shen, Master    13370115087    shenad16@hotmail.com 收起 <<
NCT00628732 Solid Tumors Phase 2 Completed - United States, Texas ... 展开 >> Children's Medical Center Dallas Dallas, Texas, United States, 75235 收起 <<

Erythromycin Ethylsuccinate 参考文献

[1]Metivier R, Bourven I, et al. Interaction of erythromycin ethylsuccinate and acetaminophen with protein fraction of extracellular polymeric substances (EPS) from various bacterial aggregates. Environ Sci Pollut Res Int. 2013 Oct;20(10):7275-85.

[2]Peeters T, Matthijs G, et al. Erythromycin is a motilin receptor agonist. Am J Physiol. 1989 Sep;257(3 Pt 1):G470-4.

[3]Latare PA, Setness PA. Using erythromycin. Some helpful observations. Postgrad Med. 1989;86(1):55‐63

[4]Lakritz J, Wilson WD, Marsh AE, Mihalyi JE. Pharmacokinetics of erythromycin ethylsuccinate after intragastric administration to healthy foals. Vet Ther. 2002;3(2):189‐195

[5]Gustafsson A, Båverud V, Gunnarsson A, Rantzien MH, Lindholm A, Franklin A. The association of erythromycin ethylsuccinate with acute colitis in horses in Sweden. Equine Vet J. 1997;29(4):314‐318

[6]Komuro I, Sunazuka T, Akagawa KS, Yokota Y, Iwamoto A, Omura S. Erythromycin derivatives inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce small isoforms of C/EBPbeta. Proc Natl Acad Sci U S A. 2008;105(34):12509‐12514

Erythromycin Ethylsuccinate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.16mL

0.23mL

0.12mL

5.80mL

1.16mL

0.58mL

11.60mL

2.32mL

1.16mL

Erythromycin Ethylsuccinate 技术信息

CAS号1264-62-6
分子式C43H75NO16
分子量 862.053
别名 EES
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature
溶解度

DMSO: 50 mg/mL(58 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 30 mg/mL(34.8 mM)，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

Tags: Erythromycin Ethylsuccinate | 1264-62-6 | Erythromycin ethyl | EES | Anti-infection | Autophagy | Bacterial | HIV | Autophagy | Antibiotic | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Erythromycin Ethylsuccinate 纯度/质量文件 | Erythromycin Ethylsuccinate 生物活性 | Erythromycin Ethylsuccinate 临床数据 | Erythromycin Ethylsuccinate 参考文献 | Erythromycin Ethylsuccinate 实验方案 | Erythromycin Ethylsuccinate 技术信息

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