货号:A118659 同义名: 25-hydroxy Vitamin D2;25-Hydroxyergocalciferol
Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.
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Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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描述 | Ercalcidiol (25(OH)D2) is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status. Differentiation between Ercalcidiol (25(OH)D2) and 25(OH)D3 is important for monitoring vitamin D therapy, as vitamin D2 is the predominant prescription form. The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and it binds less well to the vitamin D binding protein, making it less potent and, therefore, required to be administered at much higher doses than vitamin D3. Some currently used assays have a diminished capacity to detect Ercalcidiol, which can lead to dangerous overdosing when attempting to monitor therapy with vitamin D2[3]. The relations between magnesium treatment and plasma concentrations of 25(OH)D3, 25(OH)D2, and 24,25(OH)2D3 were significantly different dependent on the baseline concentrations of 25(OH)D, and significant interactions persisted after Bonferroni corrections[4]. Administration of vitamin D2 reduces 25-hydroxylation of vitamin D3 and 1-α hydroxylation of 25(OH)D3, while increasing 24R-hydroxylation of 25(OH)D3[5]. Blood spot and serum values showed excellent correlation for 25(OH)D(2) (R=0.90, n=54) and 25(OH)D(3) (R=0.91, n=83)[6]. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02323295 | Malignant Bone Tumors | Not Applicable | Recruiting | July 2019 | United States, Massachusetts ... 展开 >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Joseph Schwab, MD 617-643-2483 jhschwab@partners.org Principal Investigator: Joseph H. Schwab, MD 收起 << |
NCT03265483 | Colorectal Cancer | Not Applicable | Completed | - | United States, Tennessee ... 展开 >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37203 收起 << |
NCT02525003 | Serum 25-hydroxyvitamin D Conc... 展开 >>entrations (25OHD) 收起 << | Not Applicable | Completed | - | Finland ... 展开 >> Department of Food and Environmental Sciences, University of Helsinki Helsinki, Finland 收起 << |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.42mL 0.48mL 0.24mL |
12.12mL 2.42mL 1.21mL |
24.23mL 4.85mL 2.42mL |
CAS号 | 21343-40-8 |
分子式 | C28H44O2 |
分子量 | 412.648 |
别名 | 25-hydroxy Vitamin D2;25-Hydroxyergocalciferol;25-OH Vitamin D2.;25-Hydroxyvitamin D;25-Hydroxyecalciferol;25(OH)-Vitamin D2 |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
溶解度 |
DMSO: 190 mg/mL(460.44 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |