生物活性 | |||
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描述 | Ercalcidiol (25(OH)D2) is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status. Differentiation between Ercalcidiol (25(OH)D2) and 25(OH)D3 is important for monitoring vitamin D therapy, as vitamin D2 is the predominant prescription form. The half-life of Ercalcidiol is shorter than that of 25(OH)D3 and it binds less well to the vitamin D binding protein, making it less potent and, therefore, required to be administered at much higher doses than vitamin D3. Some currently used assays have a diminished capacity to detect Ercalcidiol, which can lead to dangerous overdosing when attempting to monitor therapy with vitamin D2[3]. The relations between magnesium treatment and plasma concentrations of 25(OH)D3, 25(OH)D2, and 24,25(OH)2D3 were significantly different dependent on the baseline concentrations of 25(OH)D, and significant interactions persisted after Bonferroni corrections[4]. Administration of vitamin D2 reduces 25-hydroxylation of vitamin D3 and 1-α hydroxylation of 25(OH)D3, while increasing 24R-hydroxylation of 25(OH)D3[5]. Blood spot and serum values showed excellent correlation for 25(OH)D(2) (R=0.90, n=54) and 25(OH)D(3) (R=0.91, n=83)[6]. |
临床研究 | |||||
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02323295 | Malignant Bone Tumors | Not Applicable | Recruiting | July 2019 | United States, Massachusetts ... 展开 >> Massachusetts General Hospital Recruiting Boston, Massachusetts, United States, 02114 Contact: Joseph Schwab, MD 617-643-2483 jhschwab@partners.org Principal Investigator: Joseph H. Schwab, MD 收起 << |
NCT03265483 | Colorectal Cancer | Not Applicable | Completed | - | United States, Tennessee ... 展开 >> Vanderbilt University Medical Center Nashville, Tennessee, United States, 37203 收起 << |
NCT02525003 | Serum 25-hydroxyvitamin D Conc... 展开 >>entrations (25OHD) 收起 << | Not Applicable | Completed | - | Finland ... 展开 >> Department of Food and Environmental Sciences, University of Helsinki Helsinki, Finland 收起 << |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.42mL 0.48mL 0.24mL |
12.12mL 2.42mL 1.21mL |
24.23mL 4.85mL 2.42mL |
参考文献 |
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