埃博霉素 A /Epothilone A {[allProObj[0].p_purity_real_show]}
货号：A408460同义名：
西洛他唑A
/ Epo A
Epothilone A是一种类似紫杉醇的微管稳定剂，EC0.01 值为 2 μM。
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Epothilone A competitively inhibits the binding of [3H] paclitaxel to tubulin polymers. The apparent Ki value for Epothilone A is 1.4 μM according to Hanes analysis and 0.6 μM according to Dixon analysis[1]. Epothilone A demonstrates high cytotoxicity (IC50=0.05 μM) in vitro against the human T-24 bladder carcinoma cell line. In competition assays, the binding affinity of Epothilone A to tubulin is comparable to that of paclitaxel. The IC50 values for displacing 100 nM of (3H) paclitaxel from the tubulin binding site are 3.6 μM for paclitaxel, 2.3 μM for Epothilone A, and 3.3 μM for patupilone[2].
体外研究
Epothilone A competitively inhibits the binding of [3H] paclitaxel to tubulin polymers. The apparent Ki value for Epothilone A is 1.4 μM according to Hanes analysis and 0.6 μM according to Dixon analysis[1].
Epothilone A demonstrates high cytotoxicity (IC50=0.05 μM) in vitro against the human T-24 bladder carcinoma cell line. In competition assays, the binding affinity of Epothilone A to tubulin is comparable to that of paclitaxel. The IC50 values for displacing 100 nM of (3H) paclitaxel from the tubulin binding site are 3.6 μM for paclitaxel, 2.3 μM for Epothilone A, and 3.3 μM for patupilone[2].
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