货号:A103432 同义名: RAD1901 dihydrochloride;Elacestrant Dihydrochloride
Elacestrant 2HCl is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities.
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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描述 | Elacestrant dihydrochloride (RAD1901), an orally administered selective degrader of estrogen receptors (SERD), shows IC50 values of 48 nM for ERα and 870 nM for ERβ. It has the capability to suppress the growth of ER+ breast cancer cells both in vitro and in vivo[1].[2]. |
体内研究 | Administered orally at dosages ranging from 0.3 to 120 mg/kg once daily for 40 days, Elacestrant dihydrochloride counteracts estrogen (E2)-induced uterine growth in a dose-responsive manner in vivo[1]. With daily oral doses of 30 and 60 mg/kg for a duration of four weeks, Elacestrant dihydrochloride achieves complete inhibition of tumor growth in mouse models[2]. The effect of inhibiting tumor growth persists for four weeks following the cessation of Elacestrant dihydrochloride treatment[2]. |
体外研究 | In a dose-dependent manner, Elacestrant dihydrochloride (RAD1901; concentration range: 0.5 nM-10 µM; duration: 48 hours) reduces ERα levels, achieving an EC50 of 0.6 nM in MCF-7 cells[1]. Elacestrant dihydrochloride, across a concentration range of 0-1 µM over 48 hours, diminishes the proliferation of Estradiol (E2)-stimulated MCF-7 cells, with the EC50 recorded at 4 pM[1]. Application of Elacestrant dihydrochloride (0-1 µM; for 24 or 48 hours) leads to a significant dose-dependent reduction in estrogen receptor protein levels in cell lines such as MCF7, T47D, and HCC1428[2]. At concentrations of 0.01, 0.1, and 1.0 µM, Elacestrant dihydrochloride lowers the expression of the progesterone receptor (PGR, PR), a target gene of the estrogen receptor, in both MCF7 and T47D cell lines[2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.88mL 0.38mL 0.19mL |
9.41mL 1.88mL 0.94mL |
18.81mL 3.76mL 1.88mL |
CAS号 | 1349723-93-8 |
分子式 | C30H40Cl2N2O2 |
分子量 | 531.557 |
别名 | RAD1901 dihydrochloride;Elacestrant Dihydrochloride |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(197.53 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 50 mg/mL(94.06 mM),配合低频超声助溶 |
动物实验配方 |