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Elacestrant 2HCl

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Chemical Structure| 1349723-93-8 同义名 : RAD1901 dihydrochloride;Elacestrant Dihydrochloride
CAS号 : 1349723-93-8
货号 : A103432
分子式 : C30H40Cl2N2O2
纯度 : 99%
分子量 : 531.557
MDL号 : N/A
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(197.53 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(94.06 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Elacestrant dihydrochloride (RAD1901), an orally administered selective degrader of estrogen receptors (SERD), shows IC50 values of 48 nM for ERα and 870 nM for ERβ. It has the capability to suppress the growth of ER+ breast cancer cells both in vitro and in vivo[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.88mL

0.38mL

0.19mL

9.41mL

1.88mL

0.94mL

18.81mL

3.76mL

1.88mL
参考文献

[1]Garner F, et al. RAD1901: a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models. Anticancer Drugs. 2015 Oct;26(9):948-56.

[2]Bihani T, et al. Elacestrant (RAD1901), a Selective Estrogen Receptor Degrader (SERD), Has Antitumor Activity in Multiple ER+ Breast Cancer Patient-derived Xenograft Models. Clin Cancer Res. 2017 Aug 15;23(16):4793-4804.