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首页 / 生化试剂 / 脂类 / 脂肪酰类 / Eicosapentaenoic Acid

花生五烯酸 /Eicosapentaenoic Acid {[allProObj[0].p_purity_real_show]}

货号：A216225 同义名： 二十碳五烯酸 / EPA;Timnodonic acid

Eicosapentaenoic Acid (EPA) 是一种 omega-3 脂肪酸，对细胞膜流动性和信号传导具有调节作用。EPA 具有抗炎、降脂和心血管保护作用，主要用于心血管疾病和慢性炎症的研究。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Eicosapentaenoic Acid 化学结构 CAS号：10417-94-4
Eicosapentaenoic Acid 化学结构
CAS号：10417-94-4
Eicosapentaenoic Acid 3D分子结构
CAS号：10417-94-4
Eicosapentaenoic Acid 化学结构 CAS号：10417-94-4
Eicosapentaenoic Acid 3D分子结构 CAS号：10417-94-4
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Eicosapentaenoic Acid 纯度/质量文件 产品仅供科研

货号：A216225 标准纯度： {[allProObj[0].p_purity_real_show]}
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Eicosapentaenoic Acid 生物活性

描述 Eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, lowers plasma triglyceride levels without raising low-density lipoprotein cholesterol levels and has potential beneficial effects on atherosclerotic plaques. EPA reduces levels of pro-inflammatory cytokines and chemokines[3]. EPA (Eicosapentaenoic Acid) may be more efficacious than DHA (docosahexaenoic acid) in treating depression[4]. The addition of eicosapentaenoic acid (EPA) to statins further reduced cardiovascular events in clinical trials, JELIS and REDUCE-IT. EPA significantly suppressed arterial calcification in vitro and in vivo via suppression of inflammatory responses, oxidative stress and Wnt signaling[5]. The effects of EPA in reducing the risk of CVD (cardiovascular disease) could be mediated by biological action of PGI3 in addition to hypotriglyceridemic action of EPA. Compared with DHA, EPA administration increases the EPA/AA ratio and the (PGI2 + PGI3)/TXA2 (thromboxane A2)balance to a state that inhibits the onset and/or progression of CVD[6]. EPA had the most favorable molecular structure, likely contributing to membrane stability, improved lipoprotein clearance, and reduced inflammation[7].

Eicosapentaenoic Acid 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01002118 Cardiovascular Disease Not Applicable Terminated(Unable to recruit e... 展开 >>ligible subjects; no data analyzed) 收起 << - United States, Iowa ... 展开 >> University of Iowa Iowa City, Iowa, United States, 52242 收起 <<
NCT03192579 Coronary Artery Disease Progre... 展开 >>ssion 收起 << Phase 4 Completed - -
NCT00350194 Metabolic Syndrome X Early Phase 1 Unknown June 2012 United States, Washington ... 展开 >> Northwest Lipid Research Clinic (University of Washington Affiliated) Seattle, Washington, United States, 98104 收起 <<

Eicosapentaenoic Acid 参考文献

[1]Martins JG. EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr. 2009 Oct;28(5):525-42.

[2]Huan M, Hamazaki K, et al. Suicide attempt and n-3 fatty acid levels in red blood cells: a case control study in China. Biol Psychiatry. 2004 Oct 1;56(7):490-6.

[3]Nelson JR, Wani O, May HT, Budoff M. Potential benefits of eicosapentaenoic acid on atherosclerotic plaques. Vascul Pharmacol. 2017 Apr;91:1-9

[4]Martins JG. EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr. 2009 Oct;28(5):525-42

[5]Saito Y, Nakamura K, Ito H. Effects of Eicosapentaenoic Acid on Arterial Calcification. Int J Mol Sci. 2020 Jul 30;21(15):5455

[6]Ohnishi H, Saito Y. Eicosapentaenoic acid (EPA) reduces cardiovascular events: relationship with the EPA/arachidonic acid ratio. J Atheroscler Thromb. 2013;20(12):861-77

[7]Sherratt SCR, Juliano RA, Mason RP. Eicosapentaenoic acid (EPA) has optimal chain length and degree of unsaturation to inhibit oxidation of small dense LDL and membrane cholesterol domains as compared to related fatty acids in vitro. Biochim Biophys Acta Biomembr. 2020 Jul 1;1862(7):183254

Eicosapentaenoic Acid 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.53mL

3.31mL

1.65mL

33.06mL

6.61mL

3.31mL

Eicosapentaenoic Acid 技术信息

CAS号10417-94-4
分子式C20H30O2
分子量 302.451
别名 二十碳五烯酸 ;EPA;Timnodonic acid;Icosapent, Eicosapentaenoic acid, Timnodonic acid, Vascepa, Epadel, EPAX;omega-3 Fatty acid;5-LOX inhibitor];C20:5 (all cis-5,8,11,14,17) Fatty acid [Anti-hyperlipoproteinenic agent;Eicosapentaenoic acid (all cis-5,8,11,14,17)
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 30 mg/mL(99.19 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(330.63 mM)，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方

Tags: Eicosapentaenoic Acid | EPA;Timnodonic acid;Icosapent, Eicosapentaenoic acid, Timnodonic acid, Vascepa, Epadel, EPAX;omega-3 Fatty acid;5-LOX inhibitor];C20:5 (all cis-5,8,11,14,17) Fatty acid [Anti-hyperlipoproteinenic agent;Eicosapentaenoic acid (all cis-5,8,11,14,17) | 二十碳五烯酸 | Aliphatic Acyl | AmBeed-信号通路专用抑制剂 | Eicosapentaenoic Acid 纯度/质量文件 | Eicosapentaenoic Acid 生物活性 | Eicosapentaenoic Acid 临床数据 | Eicosapentaenoic Acid 参考文献 | Eicosapentaenoic Acid 实验方案 | Eicosapentaenoic Acid 技术信息

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