EUK-134 is a synthetic superoxide dismutase and catalase mimetic. EUK-134 produced a significant reduction in renal dysfunction and injury caused by I/R(ischemia/reperfusion). EUK-134 significantly reduced renal injury caused by oxidative stress in vivo (reduction in PAR formation), and in vitro EUK-134 reduced PTC injury and death caused by H2O2. In vitro, EUK-134 significantly reduced NO (nitric oxide) production by PTCs (proximal tubular cell) incubated with IFN-gamma/LPS(lipopolysaccharide)[3]. Pretreatment with EUK-134 (10 μM) was effective in the prevention of hypertrophic changes in H9C2 cells, reduction of oxidative stress, and prevention of metabolic shift. EUK-134 treatment improved the oxidative status of mitochondria and reversed hypertrophy-induced reduction of mitochondrial membrane potential[4]. After a 75-min left renal artery clamping, a single intravenous injection of EUK-134 at 0.2 mg/kg, just before unclamping, provided significantly better renal function recovery during the week after the ischemic insult compared with recovery of untreated animals[5].In addition, the EUK-8 and EUK-134 improved NASH (Nonalcoholic steatohepatitis) athological features in liver of MCD(methionine/choline-deficient )-fed rats[6].
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