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EUK-134

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Chemical Structure| 81065-76-1 同义名 : -
CAS号 : 81065-76-1
货号 : A466386
分子式 : C18H18ClMnN2O4
纯度 : 97%
分子量 : 416.738
MDL号 : MFCD08059577
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 10 mg/mL(24 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 EUK-134 is a synthetic superoxide dismutase and catalase mimetic. EUK-134 produced a significant reduction in renal dysfunction and injury caused by I/R(ischemia/reperfusion). EUK-134 significantly reduced renal injury caused by oxidative stress in vivo (reduction in PAR formation), and in vitro EUK-134 reduced PTC injury and death caused by H2O2. In vitro, EUK-134 significantly reduced NO (nitric oxide) production by PTCs (proximal tubular cell) incubated with IFN-gamma/LPS(lipopolysaccharide)[3]. Pretreatment with EUK-134 (10 μM) was effective in the prevention of hypertrophic changes in H9C2 cells, reduction of oxidative stress, and prevention of metabolic shift. EUK-134 treatment improved the oxidative status of mitochondria and reversed hypertrophy-induced reduction of mitochondrial membrane potential[4]. After a 75-min left renal artery clamping, a single intravenous injection of EUK-134 at 0.2 mg/kg, just before unclamping, provided significantly better renal function recovery during the week after the ischemic insult compared with recovery of untreated animals[5].In addition, the EUK-8 and EUK-134 improved NASH (Nonalcoholic steatohepatitis) athological features in liver of MCD(methionine/choline-deficient )-fed rats[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

12.00mL

2.40mL

1.20mL

24.00mL

4.80mL

2.40mL
参考文献

[1]Jekabsone A, Mander PK, et al. Fibrillar beta-amyloid peptide Abeta1-40 activates microglial proliferation via stimulating TNF-alpha release and H2O2 derived from NADPH oxidase: a cell culture study. J Neuroinflammation. 2006 Sep 7;3:24.

[2]Baker K, Marcus CB, et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther. 1998 Jan;284(1):215-21.

[3]Chatterjee PK, Patel NS, Kvale EO, Brown PA, Stewart KN, Mota-Filipe H, Sharpe MA, Di Paola R, Cuzzocrea S, Thiemermann C. EUK-134 reduces renal dysfunction and injury caused by oxidative and nitrosative stress of the kidney. Am J Nephrol. 2004 Mar-Apr;24(2):165-77

[4]Purushothaman S, Nair RR. Mitoprotective antioxidant EUK-134 stimulates fatty acid oxidation and prevents hypertrophy in H9C2 cells. Mol Cell Biochem. 2016 Sep;420(1-2):185-94

[5]Gianello P, Saliez A, Bufkens X, Pettinger R, Misseleyn D, Hori S, Malfroy B. EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. Transplantation. 1996 Dec 15;62(11):1664-6

[6]Rezazadeh A, Yazdanparast R. Prevention of nonalcoholic steatohepatitis in rats by two manganese-salen complexes. Iran Biomed J. 2014;18(1):41-8