EIDD-1931 has a broad-spectrum antiviral activity against multiple coronaviruses, including SARS-CoV2, MERS-CoV, SARS-CoV. and related zoonotic group 2b or 2c Bat-CoVs, as well as increased potency against a coronavirus bearing resistance mutations to another nucleoside analog inhibitor.
HazMat Fee +
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Venezuelan equine encephalitis virus (VEEV) can cause widespread epidemics among humans and domestic animals. VEEV infections result in severe meningoencephalitis and long-term sequilae. EIDD-1931 is a very potent antiviral agent which effectively inhibits the replication activity of VEEV, Chikungunya virus (CHIKV) and hepatitis C virus (HCV). EIDD-1931 inhibited VEEV with EC50, EC90, and EC99 of 0.426, 1.036, and 2.5 μM, respectively. EIDD-1931 demonstrated a strong negative effect on replication of VEEV TC-83 in Vero cells. EIDD-1931 at 1 μM and 2.5 μM concentrations reduced titers of released virus progeny by 2 and 4 orders of magnitude, respectively. EIDD-1931 treatment at 2 μM concentration led to at least a 10-fold increase in accumulation of mutations. Notably, VEEV resistance to EIDD-1931 developed very inefficiently[1]. EIDD-1931 inhibited CHIKV replicon activity with an EC50 of 0.8 μM in the Huh-7-CHIKV replicon cell line. CC50 values for NHC were determined to be 30.6, 7.7 and 2.5 μM in PBM, Vero, and CEM cells, respectively[2].
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HazMat Fee +
