产品说明书
EIDD-1931
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同义名 : | - |
| CAS号 : | 3258-02-4 | |
| 货号 : | A1241627 | |
| 分子式 : | C9H13N3O6 | |
| 纯度 : | 98% | |
| 分子量 : | 259.216 | |
| MDL号 : | MFCD01675695 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(405.07 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 25 mg/mL(96.44 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Venezuelan equine encephalitis virus (VEEV) can cause widespread epidemics among humans and domestic animals. VEEV infections result in severe meningoencephalitis and long-term sequilae. EIDD-1931 is a very potent antiviral agent which effectively inhibits the replication activity of VEEV, Chikungunya virus (CHIKV) and hepatitis C virus (HCV). EIDD-1931 inhibited VEEV with EC50, EC90, and EC99 of 0.426, 1.036, and 2.5 μM, respectively. EIDD-1931 demonstrated a strong negative effect on replication of VEEV TC-83 in Vero cells. EIDD-1931 at 1 μM and 2.5 μM concentrations reduced titers of released virus progeny by 2 and 4 orders of magnitude, respectively. EIDD-1931 treatment at 2 μM concentration led to at least a 10-fold increase in accumulation of mutations. Notably, VEEV resistance to EIDD-1931 developed very inefficiently[1]. EIDD-1931 inhibited CHIKV replicon activity with an EC50 of 0.8 μM in the Huh-7-CHIKV replicon cell line. CC50 values for NHC were determined to be 30.6, 7.7 and 2.5 μM in PBM, Vero, and CEM cells, respectively[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.86mL 0.77mL 0.39mL |
19.29mL 3.86mL 1.93mL |
38.58mL 7.72mL 3.86mL |
| 参考文献 |
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