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产品名称 | HER2 ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Poziotinib |
++++
HER2, IC50: 5.3 nM |
98% | |||||||||||||||||
Tyrphostin AG 879 |
+
HER2-Neu, IC50: 1.0 μM |
95% | |||||||||||||||||
TAK-285 |
+
HER2, IC50: 17 nM |
99%+ | |||||||||||||||||
ARRY-380 analog | ✔ | 99% | |||||||||||||||||
Canertinib |
+++
ErbB2, IC50: 9.0 nM |
EGFR | 99%+ | ||||||||||||||||
(E/Z)-CP-724714 |
++
HER2/ErbB2, IC50: 10 nM |
98+% | |||||||||||||||||
Lapatinib |
+++
ErbB2, IC50: 9.2 nM |
EGFR | 98% | ||||||||||||||||
AEE788 |
++++
HER2/ErbB2, IC50: 6 nM |
EGFR | 98+% | ||||||||||||||||
Neratinib |
+
HER2, IC50: 59 nM |
Src,EGFR | 98% | ||||||||||||||||
BMS-599626 |
+
HER2, IC50: 30 nM |
99+% | |||||||||||||||||
Mubritinib |
++++
HER2/ErbB2, IC50: 6.0 nM |
99%+ | |||||||||||||||||
Tucatinib |
+++
ErbB2, IC50: 8 nM |
98% | |||||||||||||||||
Sapitinib |
++++
ErbB2, IC50: 3 nM |
EGFR | 99%+ | ||||||||||||||||
CUDC-101 |
++
HER2, IC50: 15.7 nM |
HDAC,EGFR | 99%+ | ||||||||||||||||
Afatinib dimaleate |
++
HER2, IC50: 14 nM |
98% | |||||||||||||||||
Afatinib |
++
HER2, IC50: 14 nM |
99% | |||||||||||||||||
Pertuzumab | ✔ | 95% | |||||||||||||||||
Trastuzumab | ✔ | 99% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Product Name: Disitamab Corss-reactivity: Human,Mouse,Rat,Cynomolgus Organism:Human Target name: ERBB2 / HER2 / CD340 Recommended Dilution Buffer: Sterile PBS or 0.9% saline for reconstitution/dilution. It is recommended to use the reconstituted/diluted product within one month. Formulation: 100 mM Pro-Ac,20 mM Arg,pH5.0 Endotoxin: < 0.001EU/μg, determined by LAL method. Purity: >95%. Determined by SDS-PAGE Purification: Purified, Protein A, affinity column Storage: -80°C for 2 years under sterile conditions; -20°C for 1 year under sterile conditions; Avoid repeated freeze-thaw cycles. Isotype: IgG1 |
CAS号 | 2185868-98-6 |
分子式 | |
分子量 |
别名 | RC48-0 |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 |
溶解度 | |
动物实验配方 |