There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Transient receptor potential ankyrin 1 (TRPA1) is a Ca2+-permeable nonselective cation channel expressed in neuronal and nonneuronal cells and plays an important role in acute and inflammatory pain. Diphenyleneiodonium chloride (DPI), a NADPH oxidase (NOX) inhibitor, also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Application of DPI at 0.03-10 μM induced a Ca2+ response in HEK-TRPA1 cells in a concentration-dependent manner. In inflammatory human synoviocytes where TRPA1 is functionally expressed, 3 μM DPI evoked a Ca2+ response when cells were treated with IL1α suggesting that DPI activates endogenous TRPA1 expressed in human synoviocytes[3]. In human RPE cell line ARPE-19 cells, DPI (0.1, 1, and 10 μM) resulted in a significant decrease of cell proliferation, without vacuolation and detachment of the cells from the dish. Significantly increased level of p53 was detected at 4 h after treatment of DPI[4]. In mice, intraplantar injection of 2 mM DPI caused a pain-related response which was inhibited by preadministration with HC (a selective TRPA1 antagonist, HC-030031)[3].
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