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/ 组织蛋白酶 / Dimethadione

5,5-二甲基噁唑烷-2,4-二酮 /Dimethadione {[allProObj[0].p_purity_real_show]}

货号：A181810 同义名： 二甲双酮

5,5-Dimethyl-2,4-oxazolidinedione is a cathepsin K inhibitor, it's an anticonvulsant.

Dimethadione 化学结构 CAS号：695-53-4
Dimethadione 化学结构
CAS号：695-53-4
Dimethadione 3D分子结构
CAS号：695-53-4
Dimethadione 化学结构 CAS号：695-53-4
Dimethadione 3D分子结构 CAS号：695-53-4
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Dimethadione 纯度/质量文件 产品仅供科研

货号：A181810 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Dimethadione 生物活性

描述 5,5'-Dimethyloxazolidine-2,4-dione (DMO), a weak non-metabolizable acid, is commonly utilized for determining intracellular pH. In these studies, DMO was tested as an inducer of differentiation on the basis that its uptake and subsequent dissociation might transiently raise intracellular pH and activate ion-fluxes critical for triggering maturation. After 5 days of exposure to 40 mM DMO, greater than 60% of HL-60 cells displayed phenotypic and functional changes characteristic of mature granulocytes. DMO was either weak or inactive as an inducer of murine erythroleukemia cell (FLC) differentiation[2]. Determination of the overall internal pH of the cells, using (14)C-benzoic acid (BA) or DMO, showed that the cells maintain a neutral pH (6.6 to 7.2) over an external pH range of 3.0-7.0[3]. The internal pH of S. petersenii determined using (14)C-benzoic acid and [2-(14)C]-5,5-dimethyloxazolidine-2,4-dione was pH 7.0-7.5, over an external pH range of 5.0-7.5[4]. The glucose effect on DMO uptake was concentration-dependent, with half-maximal effect at about 4 mM-glucose and maximum effect at about 10 mM-glucose[5].

Dimethadione 参考文献

[2]Calderon TM, Schneiderman N, Michl J, Christman JK. 5,5'-Dimethyloxazolidine-2,4-dione is a strong inducer of differentiation of human promyelocytic leukemia (HL-60) cells. Cell Differ Dev. 1989 May;26(3):181-90

[3]Balkos KD, Colman B. Mechanism of CO2 acquisition in an acid-tolerant Chlamydomonas. Plant Cell Environ. 2007 Jun;30(6):745-52

[4]Bhatti S, Colman B. Inorganic carbon acquisition in some synurophyte algae. Physiol Plant. 2008 May;133(1):33-40

[5]Lindström P, Sehlin J. Effect of glucose on the intracellular pH of pancreatic islet cells. Biochem J. 1984 Mar 15;218(3):887-92

Dimethadione 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

7.75mL

1.55mL

0.77mL

38.73mL

7.75mL

3.87mL

77.45mL

15.49mL

7.75mL

Dimethadione 技术信息

CAS号695-53-4
分子式C5H7NO3
分子量 129.114
别名 二甲双酮
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度

DMSO: 105 mg/mL(813.23 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Dimethadione | 695-53-4 | Drug Metabolite | Trimethadione | Metabolic Enzyme/Protease | Drug Metabolite | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Dimethadione 纯度/质量文件 | Dimethadione 生物活性 | Dimethadione 参考文献 | Dimethadione 实验方案 | Dimethadione 技术信息

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