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己烯雌酚 /Diethylstilbestrol {[allProObj[0].p_purity_real_show]}

货号:A174248 同义名: Stilbestrol

Diethylstilbestrol是一种合成的非类固醇雌激素,产生与天然雌二醇相同的药理学和治疗效应。主要用于治疗因雌激素缺乏和激素失衡引起的功能性出血和闭经。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Diethylstilbestrol 化学结构 CAS号:56-53-1
Diethylstilbestrol 化学结构
CAS号:56-53-1
Diethylstilbestrol 3D分子结构
CAS号:56-53-1
Diethylstilbestrol 化学结构 CAS号:56-53-1
Diethylstilbestrol 3D分子结构 CAS号:56-53-1
规格 价格 会员价 库存 数量
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Diethylstilbestrol 纯度/质量文件 产品仅供科研

货号:A174248 标准纯度: {[allProObj[0].p_purity_real_show]}
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Diethylstilbestrol 生物活性

描述 Diethylstilbestrol is a synthetic estrogen receptor agonist structurally related to estradiol. Diethylstilbestrol at 20µM results in 30±13% and 43±4% displacement of [3H]-estradiol from the sex hormone-binding globulin steroid-binding site in the serum and dextran-coated charcoal-treated serum[3]. Prostate cancer PC-3 cells treated with 30µM diethylstilbestrol for 72 hours show smaller nuclei compared with the control group. Diethylstilbestrol at 15 and 30µM induces apoptosis of androgen-insensitive prostate cancer cells[4].

Diethylstilbestrol 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00428948 Polycystic Kidney Disease, Aut... 展开 >>osomal Dominant 收起 << Phase 3 Completed - -
NCT00428948 - Completed - -
NCT01212991 Prostate Cancer Phase 3 Active, not recruiting December 28, 2018 -

Diethylstilbestrol 参考文献

[1]Tremblay GB, Kunath T, et al. Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. Genes Dev. 2001 Apr 1;15(7):833-8.

[2]Sharpe RM, Atanassova N, et al. Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development. Biol Reprod. 1998 Nov;59(5):1084-94.

[3]Hodgert Jury H, Zacharewski TR, Hammond GL. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J Steroid Biochem Mol Biol. 2000;75(2-3):167-176.

[4]Robertson CN, Roberson KM, Padilla GM, et al. Induction of apoptosis by diethylstilbestrol in hormone-insensitive prostate cancer cells. J Natl Cancer Inst. 1996;88(13):908-917.

Diethylstilbestrol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.73mL

0.75mL

0.37mL

18.63mL

3.73mL

1.86mL

37.26mL

7.45mL

3.73mL

Diethylstilbestrol 技术信息

CAS号56-53-1
分子式C18H20O2
分子量 268.35
别名 Stilbestrol
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Room Temperature

溶解方案

DMSO: 50 mg/mL(186.32 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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