Diethylstilbestrol

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Chemical Structure| 56-53-1 同义名 : Stilbestrol
CAS号 : 56-53-1
货号 : A174248
分子式 : C18H20O2
纯度 : 98%
分子量 : 268.35
MDL号 : MFCD00002373
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(186.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Diethylstilbestrol is a synthetic estrogen receptor agonist structurally related to estradiol. Diethylstilbestrol at 20µM results in 30±13% and 43±4% displacement of [3H]-estradiol from the sex hormone-binding globulin steroid-binding site in the serum and dextran-coated charcoal-treated serum[3]. Prostate cancer PC-3 cells treated with 30µM diethylstilbestrol for 72 hours show smaller nuclei compared with the control group. Diethylstilbestrol at 15 and 30µM induces apoptosis of androgen-insensitive prostate cancer cells[4].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00428948 Polycystic Kidney Disease, Aut... 展开 >>osomal Dominant 收起 << Phase 3 Completed - -
NCT00428948 - Completed - -
NCT01212991 Prostate Cancer Phase 3 Active, not recruiting December 28, 2018 -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.73mL

0.75mL

0.37mL

18.63mL

3.73mL

1.86mL

37.26mL

7.45mL

3.73mL
参考文献

[1]Tremblay GB, Kunath T, et al. Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERR beta. Genes Dev. 2001 Apr 1;15(7):833-8.

[2]Sharpe RM, Atanassova N, et al. Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development. Biol Reprod. 1998 Nov;59(5):1084-94.

[3]Hodgert Jury H, Zacharewski TR, Hammond GL. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J Steroid Biochem Mol Biol. 2000;75(2-3):167-176.

[4]Robertson CN, Roberson KM, Padilla GM, et al. Induction of apoptosis by diethylstilbestrol in hormone-insensitive prostate cancer cells. J Natl Cancer Inst. 1996;88(13):908-917.