Diaveridine HCl is a coccidiostat and inhibits dihydrofolate reductase. It can prevente folic acid synthesis in species of Pneumocystis. Diaveridine also has genotoxicity.
Diaveridine (DVD) HCl is a popular antibacterial synergist that is widely used in combination with sulfonamide[1]. Thirty healthy chickens were orally administered with sulphachloropyrazine-diaveridine (SPZ-DVD) suspension in water of 300 mg/l (SPZ) per day for seven successive days. The withdrawal period of DVD was 4.77, 4.94, 6.74 and 4.58 days in muscle, liver, kidney and skin with fat, respectively. Therefore, the suggested withdrawal period for SPZ-DVD suspension should be 7 days after dosing for seven successive days[2]. Diaveridine, a developed dihydrofolate reductase inhibitor, has been widely used as anticoccidial drug and antibacterial synergist. Calculated LD50 was 2330 mg/kg b.w. in females and 3100 mg/kg b.w. in males, and chromodacryorrhea was noted in some females before their death[3].
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