规格 | 价格 | 会员价 | 库存 | 数量 | |||
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{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
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免费溶解
产品名称 | HIF ↓ ↑ | HIF1 ↓ ↑ | PHD1 ↓ ↑ | PHD2 ↓ ↑ | PHD3 ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
KC7F2 |
+
HIF-1α, IC50: 20 μM |
+
HIF-1α, IC50: 20 μM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Lificiguat | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
BAY 87-2243 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
PX-478·2HCl | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
2-Methoxyestradiol | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
CAY10585 |
++
HIF, IC50: 4.4 μM |
BCRP | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
DMOG | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
FG 2216 |
++
PHD2, IC50: 3.9 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
MK-8617 |
++++
PHD1, IC50: 1 nM |
++++
PHD2, IC50: 1 nM |
++++
PHD3, IC50: 14 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Desidustat is a pan-PHD (prolyl hydroxylase) inhibitor used for the treatment of chronic kidney disease-induced anemia, acting by inducing erythropoiesis by stabilizing hypoxia-inducible factor (HIF). A single dose treatment of 15mg/kg Desidustat attenuated the effect of LPS or turpentine oil-induced inflammation and increased serum erythropoietin, iron, and reticulocyte count, and decreased serum hepcidin levels. Repeated treatment of Desidustat at dose ranging in 5-50mg/kg increased hemoglobin, RBC and hematocrit in a dose related manner in turpentine oil-induced anemia in BALB/c mice. Desidustat at dose of 15mg/kg and 30mg/kg markedly reduced PGPS-induced anemia and increased hemoglobin, RBC and WBC count, hematocrit, serum iron and spleen iron in female Lewis rats. Meanwhile, it caused a significant increase in expression of DcytB, FPN1, DMT1, MCP-1 in liver, suggesting an overall influence on iron metabolism. |
Dose | Rat: 15 mg/kg[2] (p.o.) Mice: 5 mg/kg - 50 mg/kg[3] (p.o.) | ||||||||||||||||
Administration | p.o. | ||||||||||||||||
Pharmacokinetics |
|
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.01mL 0.60mL 0.30mL |
15.05mL 3.01mL 1.50mL |
30.09mL 6.02mL 3.01mL |
CAS号 | 1616690-16-4 |
分子式 | C16H16N2O6 |
分子量 | 332.31 |
别名 | ZYAN1;Taleranol;Desidustat, ZYan1;β-Zearanol;β-Zearalanol;P 1560;ZYAN1-1001 |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 9 mg/mL(27.08 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |