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货号:A116839 同义名: CGP 37391;DN 18001AF Ambeed 开学季,买赠积分,赢豪礼

Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload. Target: Deferiprone is an orphan drug designed and developed primarily by academic initiatives for the treatment of iron overload in thalassaemia. Deferiprone has been used in several other iron or other metal imbalance conditions and has prospects of wider clinical applications. Deferiprone has high affinity for iron and interacts with almost all the iron pools at the molecular, cellular, tissue and organ levels. Doses of 50-120 mg/kg/day appear to be effective in bringing patients to negative iron balance. Deferiprone increases urinary iron excretion, which mainly depends on the iron load of patients and the dose of the drug.

Deferiprone 化学结构 CAS号:30652-11-0
Deferiprone 化学结构
CAS号:30652-11-0
Deferiprone 3D分子结构
CAS号:30652-11-0
Deferiprone 化学结构 CAS号:30652-11-0
Deferiprone 3D分子结构 CAS号:30652-11-0
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Deferiprone 纯度/质量文件 产品仅供科研

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Deferiprone 生物活性

描述 Deferiprone is a potent iron chelating agent that is orally active, capable of penetrating the brain, cells, and skin. It is effective in inhibiting tumor cell proliferation and migration, while also promoting apoptosis. Additionally, deferiprone possesses anti-anemic, neuroprotective, anti-inflammatory, antioxidant, and antidotal properties, making it useful in studies related to cancer, cardiovascular disease, infection, inflammation, and neurological diseases[1].[2].[3].[4].[5].[6].[7].[8].
体内研究

Deferiprone (100 mg/kg daily for 4 weeks, ingested) demonstrates a neuroprotective effect in a mouse model of tauopathy, the rTg(tauP301L)4510[6].

Deferiprine (50-200 mg/kg daily, orally for 5-10 days) alleviates nephrotoxicity in a rat model of acute renal failure induced by Cisplatin[7].

Deferiprone (13.82 and 27.64 mg/kg per day, ingested for 4 weeks) exhibits anti-apoptotic and neuroprotective activities in a rat model of Alzheimer’s disease[8].

体外研究

Deferiprone (ranging from 66 to 660 μM, over 48 to 96 hours) significantly inhibits cell proliferation in TRAMP-C2, Myc-CaP, and 22rv1 cells[1].

At a concentration of 100 μM and up to 192 hours, deferiprone hampers cell migration in the same cell lines[1].

Deferiprone (100 μM, 24 hours) reduces both the expression and activity of mitochondrial aconitase (m-Acon) in TRAMP-C2, Myc-CaP, and 22rv1 cells[1].

Deferiprone (up to 1 μM, between 0.5 and 24 hours) lowers free iron levels in thalassemic red blood cells[2].

Deferiprone (10 minutes) inhibits human platelet aggregation stimulated by arachidonic acid (AA), adenosine diphosphate (ADP), epinephrine, and collagen, with IC50 values of 0.24, 0.25, 3.36, and 3.73 mM, respectively[3].

Deferiprone (0.1-3.2 μM, 5 minutes) inhibits COX-1 activity with an IC50 of 0.33 μM[3].

Deferiprone (4 mM, 5 minutes) prevents ADP-induced formation of cAMP[3].

Deferiprone (156.25 μg/mL, 24 hours) enhances the survival rate and reduces LDH levels, maintaining normal cell morphology in aged fibroblasts[4].

Deferiprone (25 μM, 6 hours) increases the antibacterial efficacy of conventional antibiotics against S. epidermidis[5].

Deferiprone 参考文献

[1]Rui V. Simões, Inhibition of prostate cancer proliferation by Deferiprone. NMR Biomed

[2]Oded Shalev. et al. Deferiprone (L1) Chelates Pathologic Iron Deposits From Membranes of Intact Thalassemic and Sickle Red Blood Cells Both In Vitro and In Vivo.

[3]Ngan Thi Tran, et al. Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition. Platelets 2020 May 18;31(4):505-512.

[4]Andrea Pagani, MD, et al. Deferiprone Stimulates Aged Dermal Fibroblasts via HIF-1α Modulation.Pathog Dis. 2018 Jul 1;76(5).

[5]Débora C Coraça-Huber, et al. Iron chelation destabilizes bacterial biofilms and potentiates the antimicrobial activity of antibiotics against coagulase-negative Staphylococci. Pathogens and Disease, Volume 76, Issue 5, July 2018, fty052

[6]Shalini S. Rao, et al. Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology. Neurotherapeutics. 2021 Apr;18(2):1081-1094.

[7]Makhdoumi P, et al. Oral deferiprone administration ameliorates cisplatin-induced nephrotoxicity in rats.J Pharm Pharmacol. 2018 Oct;70(10):1357-1368.

[8]Yanan Zhang, et al. Taurine and deferiprone against Al-linked apoptosis in rat hippocampus. J Trace Elem Med Biol. 2023 Mar;76:127113.

Deferiprone 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

7.19mL

1.44mL

0.72mL

35.93mL

7.19mL

3.59mL

71.86mL

14.37mL

7.19mL

Deferiprone 技术信息

CAS号30652-11-0
分子式C7H9NO2
分子量 139.152
别名 CGP 37391;DN 18001AF;Ferriprox
运输蓝冰
存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 6 mg/mL(43.12 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 3 mg/mL(21.56 mM),配合低频超声助溶

动物实验配方
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