产品说明书

Deferiprone

Print
Chemical Structure| 30652-11-0 同义名 : CGP 37391;DN 18001AF;Ferriprox
CAS号 : 30652-11-0
货号 : A116839
分子式 : C7H9NO2
纯度 : 98%
分子量 : 139.152
MDL号 : MFCD00134497
存储条件:

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 6 mg/mL(43.12 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 3 mg/mL(21.56 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 Deferiprone is a potent iron chelating agent that is orally active, capable of penetrating the brain, cells, and skin. It is effective in inhibiting tumor cell proliferation and migration, while also promoting apoptosis. Additionally, deferiprone possesses anti-anemic, neuroprotective, anti-inflammatory, antioxidant, and antidotal properties, making it useful in studies related to cancer, cardiovascular disease, infection, inflammation, and neurological diseases[1].[2].[3].[4].[5].[6].[7].[8].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

7.19mL

1.44mL

0.72mL

35.93mL

7.19mL

3.59mL

71.86mL

14.37mL

7.19mL

参考文献

[1]Rui V. Simões, Inhibition of prostate cancer proliferation by Deferiprone. NMR Biomed

[2]Oded Shalev. et al. Deferiprone (L1) Chelates Pathologic Iron Deposits From Membranes of Intact Thalassemic and Sickle Red Blood Cells Both In Vitro and In Vivo.

[3]Ngan Thi Tran, et al. Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition. Platelets 2020 May 18;31(4):505-512.

[4]Andrea Pagani, MD, et al. Deferiprone Stimulates Aged Dermal Fibroblasts via HIF-1α Modulation.Pathog Dis. 2018 Jul 1;76(5).

[5]Débora C Coraça-Huber, et al. Iron chelation destabilizes bacterial biofilms and potentiates the antimicrobial activity of antibiotics against coagulase-negative Staphylococci. Pathogens and Disease, Volume 76, Issue 5, July 2018, fty052

[6]Shalini S. Rao, et al. Deferiprone Treatment in Aged Transgenic Tau Mice Improves Y-Maze Performance and Alters Tau Pathology. Neurotherapeutics. 2021 Apr;18(2):1081-1094.

[7]Makhdoumi P, et al. Oral deferiprone administration ameliorates cisplatin-induced nephrotoxicity in rats.J Pharm Pharmacol. 2018 Oct;70(10):1357-1368.

[8]Yanan Zhang, et al. Taurine and deferiprone against Al-linked apoptosis in rat hippocampus. J Trace Elem Med Biol. 2023 Mar;76:127113.