Darutoside is a diterpenoid isolated from Siegesbeckia. Five diterpenoids were obtained from the fraction D_(50) with the strongest PPARγ activity among others in SPA (Siegesbeckia pubescens), and determined as kirenol(1), darutigenol(2), enantiomeric-2-ketone-15,16,19-three hydroxypinomane-8(14) -ene-19- O-β-D- glucoside(3), darutoside(4), enantiomeric-2-β,15,16,19-four hydroxypinomane-8(14)-ene-19-O-β-D-glucoside(5), respectively. All the compounds exhibited active effects on PPARγ in a concentration-dependent manner. The diterpenoids 1-5 isolated from S. pubescens have the PPARγ activation activities and potential effects of anti-UC in vitro[2]. Three diterpenes including a new compound were isolated from the whole plant of Siegesbeckia glabrescens Mak. The new one was named as neodarutoside and its structure was elucidated as ent-3 alpha, 15,16-trihydroxy pimarane 3,15-bis-(beta-glucopyranoside) based on the spectral evidence and chemical transformation. Darutoside possesses the activity of termination of early pregnancy in experimental rats at a dosage of 20-40 mg/kg[3].
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