产品说明书
Darutoside
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同义名 : | - |
| CAS号 : | 59219-65-7 | |
| 货号 : | A1004899 | |
| 分子式 : | C26H44O8 | |
| 纯度 : | 98% | |
| 分子量 : | 484.623 | |
| MDL号 : | MFCD17214820 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(216.66 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Darutoside is a diterpenoid isolated from Siegesbeckia. Five diterpenoids were obtained from the fraction D_(50) with the strongest PPARγ activity among others in SPA (Siegesbeckia pubescens), and determined as kirenol(1), darutigenol(2), enantiomeric-2-ketone-15,16,19-three hydroxypinomane-8(14) -ene-19- O-β-D- glucoside(3), darutoside(4), enantiomeric-2-β,15,16,19-four hydroxypinomane-8(14)-ene-19-O-β-D-glucoside(5), respectively. All the compounds exhibited active effects on PPARγ in a concentration-dependent manner. The diterpenoids 1-5 isolated from S. pubescens have the PPARγ activation activities and potential effects of anti-UC in vitro[2]. Three diterpenes including a new compound were isolated from the whole plant of Siegesbeckia glabrescens Mak. The new one was named as neodarutoside and its structure was elucidated as ent-3 alpha, 15,16-trihydroxy pimarane 3,15-bis-(beta-glucopyranoside) based on the spectral evidence and chemical transformation. Darutoside possesses the activity of termination of early pregnancy in experimental rats at a dosage of 20-40 mg/kg[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.06mL 0.41mL 0.21mL |
10.32mL 2.06mL 1.03mL |
20.63mL 4.13mL 2.06mL |
| 参考文献 |
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[2]Gao LJ, Xu SF, Li XY, Huang WK, Hao SJ, Ye YP. Zhongguo Zhong Yao Za Zhi. 2019;44(23):5191-5197 [3]Dong XY, Chen M, Jin W, Huang DX, Shen SM, Li HT. Yao Xue Xue Bao. 1989;24(11):833‐836 |