There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
DKM 2-93 inhibits the catalytic cysteine of UBA5 through covalent modification, thereby suppressing its protein activity as an enzyme that activates the ubiquitin-like protein UFM1 to UFMylation, ultimately impairing the survival of pancreatic cancer cells. DKM 2-93 hinders the survival of PaCa2 and Panc1 cells, with IC50 values of 90 and 30 μM, respectively[1].
DKM 2-93 动物研究
Animal study
In tumor xenograft studies on immunodeficient mice, daily administration of DKM 2-93 significantly impaired the in vivo tumor growth of PaCa2 cells without causing any weight loss or apparent toxicity[1].
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