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描述 | DDO-5936 is a potent, specific inhibitor of the Hsp90-Cdc37 protein-protein interaction (PPI), useful for research in colorectal cancer [1]. |
体内研究 | DDO-5936 (0~80 mg/kg; orally) is effective in the high dose group [1]. DDO-5936 is well tolerated due to the lack of significant weight loss. In high dose groups, DDO-5936 significantly reduces tumor cells in xenografts. However, DDO-5936 has limited oral efficacy [1]. |
体外研究 | DDO-5936 binds to a crucial site on Hsp90 involving Glu47, exhibiting both potency and specificity as an Hsp90-Cdc37 PPI inhibitor [1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.02mL 0.40mL 0.20mL |
10.09mL 2.02mL 1.01mL |
20.18mL 4.04mL 2.02mL |
CAS号 | 2355377-13-6 |
分子式 | C25H29N5O4S |
分子量 | 495.594 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 12 mg/mL(24.21 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |