货号:A116007 同义名: Astramembrangenin;Cyclosieversigenin
Cycloastragenol exhibits telomerase activation activity and can be extracted from various species in the genus Astragalus.
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产品名称 | Telomerase ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
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4',7-Dimethoxyisoflavone | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
BIBR 1532 |
+++
Telomerase, IC50: 100 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Costunolide |
++
Telomerase (MCF-7), IC50: 90 μM Telomerase (MDA-MB-231), IC50: 65 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Cycloastragenol (CAG) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge. CAG activates telomerase in humans and ameliorates various biomarkers. CAG is absorbed through the intestinal epithelium via passive diffusion and undergoes first-pass hepatic metabolism. Within a certain dose range, oral CAG is relatively safe[1]. CAG (5, 10, 20 mg/kg) dose-dependently reduced brain infarct volume, significantly ameliorated functional deficits, and prevented neuronal cell loss in MCAO (middle cerebral artery occlusion) mice. Meanwhile, CAG significantly reduced matrix metalloproteinase-9 activity, prevented tight junction degradation and subsequently ameliorated blood-brain barrier disruption. Moreover, CAG significantly upregulated SIRT1 expression in the ischemic brain but did not directly activate its enzymatic activity[2]. CAG alleviates age-related bone loss and improves bone microstructure and biomechanical properties[3]. CAG improved the chondrogenic differentiation of hAMSCs(human adipose-derived mesenchymal stem cells), maintaining stable the active chondrocyte phenotype in up to 28 days of 3D in vitro chondrogenic culture[4]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.04mL 0.41mL 0.20mL |
10.19mL 2.04mL 1.02mL |
20.38mL 4.08mL 2.04mL |
CAS号 | 78574-94-4 |
分子式 | C30H50O5 |
分子量 | 490.715 |
别名 | Astramembrangenin;Cyclosieversigenin;Cyclogalegenol |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 65 mg/mL(132.46 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |