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Cycloastragenol

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Chemical Structure| 78574-94-4 同义名 : Astramembrangenin;Cyclosieversigenin;Cyclogalegenol
CAS号 : 78574-94-4
货号 : A116007
分子式 : C30H50O5
纯度 : 98%
分子量 : 490.715
MDL号 : MFCD24849201
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 65 mg/mL(132.46 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Cycloastragenol (CAG) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge. CAG activates telomerase in humans and ameliorates various biomarkers. CAG is absorbed through the intestinal epithelium via passive diffusion and undergoes first-pass hepatic metabolism. Within a certain dose range, oral CAG is relatively safe[1]. CAG (5, 10, 20 mg/kg) dose-dependently reduced brain infarct volume, significantly ameliorated functional deficits, and prevented neuronal cell loss in MCAO (middle cerebral artery occlusion) mice. Meanwhile, CAG significantly reduced matrix metalloproteinase-9 activity, prevented tight junction degradation and subsequently ameliorated blood-brain barrier disruption. Moreover, CAG significantly upregulated SIRT1 expression in the ischemic brain but did not directly activate its enzymatic activity[2]. CAG alleviates age-related bone loss and improves bone microstructure and biomechanical properties[3]. CAG improved the chondrogenic differentiation of hAMSCs（human adipose-derived mesenchymal stem cells）, maintaining stable the active chondrocyte phenotype in up to 28 days of 3D in vitro chondrogenic culture[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.04mL

0.41mL

0.20mL

10.19mL

2.04mL

1.02mL

20.38mL

4.08mL

2.04mL
参考文献

[1]Yu Y, Zhou L, Yang Y, Liu Y. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018 Sep;16(3):2175-2182

[2]Li M, Li SC, Dou BK, Zou YX, Han HZ, Liu DX, Ke ZJ, Wang ZF. Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. Acta Pharmacol Sin. 2020 Aug;41(8):1025-1032

[3]Yu Y, Wu J, Li J, Liu Y, Zheng X, Du M, Zhou L, Yang Y, Luo S, Hu W, Li L, Yao W, Liu Y. Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats. Biomed Pharmacother. 2020 Aug;128:110304

[4]Szychlinska MA, Calabrese G, Ravalli S, Parrinello NL, Forte S, Castrogiovanni P, Pricoco E, Imbesi R, Castorina S, Leonardi R, Di Rosa M, Musumeci G. Cycloastragenol as an Exogenous Enhancer of Chondrogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells. A Morphological Study. Cells. 2020 Feb 3;9(2):347