氯吡格雷 /Clopidogrel
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货号：A111444
同义名：
Clopidogrelum
Clopido grel是一种口服活性的P2Y12受体拮抗剂，用于抑制冠状动脉疾病、外周血管疾病和脑血管疾病中的血栓形成。
Clopidogrel 化学结构
Clopidogrel 3D分子结构
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Clopidogrel 纯度/质量文件 产品仅供科研
货号：A111444
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Clopidogrel 质控信息
Clopidogrel 生物活性
描述
The P2Y12 receptor, activated by ADP, plays a central role in platelet activation that have proven therapeutic value. Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of P2Y12 receptor (IC50=100nM)[3] [4] [5]
Clopidogrel 参考文献
[1] Focks JJ, Brouwer MA, et al. Concomitant use of clopidogrel and proton pump inhibitors: impact on platelet function and clinical outcome- a systematic review. Heart. 2013 Apr;99(8):520-7.
[2] von Kugelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther. 2006 Jun;110(3):415-32.
[3] Savi P, Labouret C, Delesque N, Guette F, Lupker J, Herbert JM. P2y(12), a new platelet ADP receptor, target of clopidogrel. Biochem Biophys Res Commun. 2001;283(2):379-383.
[4] Zheng Z, Ma T, Lian X, et al. Clopidogrel Reduces Fibronectin Accumulation and Improves Diabetes-Induced Renal Fibrosis. Int J Biol Sci. 2019;15(1):239-252.
[5] An insight into the interaction between clopidogrel and proton pump inhibitors By Shah, Bhavik S.; Parmar, Sanjay A.; Mahajan, Shailaja; Mehta, Anita A. From Current Drug Metabolism (2012), 13(2),225-235.
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Clopidogrel 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.11mL
0.62mL
0.31mL
15.54mL
3.11mL
1.55mL
31.07mL
6.21mL
3.11mL
Clopidogrel 技术信息
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