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描述 | The P2Y12 receptor, activated by ADP, plays a central role in platelet activation that have proven therapeutic value. Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of P2Y12 receptor (IC50=100nM)[3]. Clopidogrel, administered during the last three months, significantly decreases blood glucose, collagen and fibronectin expression compared to vehicle-treated diabetic mice. Clopidogrel markedly ameliorates hyperglycemia-induced renal fibrosis[4]. The combination therapy of clopidogrel and aspirin (dual-antiplatelet therapy) has been shown to be significantly beneficial compared to aspirin monotherapy and has also shown to decrease sub-acute stent thrombosis as well as recurrent ischemic events following ACS[5]. |
计算器 | ||||
存储液制备 | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.11mL 0.62mL 0.31mL |
15.54mL 3.11mL 1.55mL |
31.07mL 6.21mL 3.11mL |
CAS号 | 113665-84-2 |
分子式 | C16H16ClNO2S |
分子量 | 321.82 |
别名 | Clopidogrelum |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 50 mg/mL(155.37 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |