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Clopidogrel

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Chemical Structure| 113665-84-2 同义名 : Clopidogrelum
CAS号 : 113665-84-2
货号 : A111444
分子式 : C16H16ClNO2S
纯度 : 98%
分子量 : 321.82
MDL号 : MFCD05662337
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(155.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The P2Y12 receptor, activated by ADP, plays a central role in platelet activation that have proven therapeutic value. Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of P2Y12 receptor (IC50=100nM)[3]. Clopidogrel, administered during the last three months, significantly decreases blood glucose, collagen and fibronectin expression compared to vehicle-treated diabetic mice. Clopidogrel markedly ameliorates hyperglycemia-induced renal fibrosis[4]. The combination therapy of clopidogrel and aspirin (dual-antiplatelet therapy) has been shown to be significantly beneficial compared to aspirin monotherapy and has also shown to decrease sub-acute stent thrombosis as well as recurrent ischemic events following ACS[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.11mL

0.62mL

0.31mL

15.54mL

3.11mL

1.55mL

31.07mL

6.21mL

3.11mL
参考文献

[1]Focks JJ, Brouwer MA, et al. Concomitant use of clopidogrel and proton pump inhibitors: impact on platelet function and clinical outcome- a systematic review. Heart. 2013 Apr;99(8):520-7.

[2]von Kugelgen I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther. 2006 Jun;110(3):415-32.

[3]Savi P, Labouret C, Delesque N, Guette F, Lupker J, Herbert JM. P2y(12), a new platelet ADP receptor, target of clopidogrel. Biochem Biophys Res Commun. 2001;283(2):379-383.

[4]Zheng Z, Ma T, Lian X, et al. Clopidogrel Reduces Fibronectin Accumulation and Improves Diabetes-Induced Renal Fibrosis. Int J Biol Sci. 2019;15(1):239-252.

[5] An insight into the interaction between clopidogrel and proton pump inhibitors By Shah, Bhavik S.; Parmar, Sanjay A.; Mahajan, Shailaja; Mehta, Anita A. From Current Drug Metabolism (2012), 13(2),225-235.