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/ Clobetasol propionate

丙酸氯倍他索 /Clobetasol propionate {[allProObj[0].p_purity_real_show]}

货号：A505172 同义名： CCl-4725;CGP9555

Clobetasol propionate是一种类固醇药物，具有抗炎作用，常用于治疗各种皮肤疾病。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Clobetasol propionate 化学结构 CAS号：25122-46-7
Clobetasol propionate 化学结构
CAS号：25122-46-7
Clobetasol propionate 3D分子结构
CAS号：25122-46-7
Clobetasol propionate 化学结构 CAS号：25122-46-7
Clobetasol propionate 3D分子结构 CAS号：25122-46-7
规格 价格 会员价 库存 数量
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Clobetasol propionate 纯度/质量文件 产品仅供科研

货号：A505172 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Clobetasol propionate 生物活性

描述 Clobetasol propionate is a corticosteroid[2]. Clobetasol propionate is the most potent of all topical steroids. It is successfully applied in the treatment of various skin diseases such as atopic dermatitis, psoriasis and vulvar lichen sclerosus. Clobetasol propionate exerts anti-inflammatory, immunosuppressive and antimitotic effects influencing the growth, differentiation and function of various cells and inhibiting cytokine production[3]. Clobetasol propionate (applied topically; daily for 14 days) reduces the epidermal thickness of both normal and psoriatic skin in human psoriatic skin-SCID mouse transplant model topical application[4]. When compared with calcipotriene/betamethasone dipropionate ointment, clobetasol propionate 0.05% spray produced greater rates of lesion clearance and similar improvement in QOL scores after 2 or 4 weeks of treatment. Clobetasol propionate 0.05% spray is an efficacious and safe treatment for plaque psoriasis and produces significant improvement in QOL for affected patients[5].

Clobetasol propionate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00544687 Healthy Phase 1 Completed - Germany ... 展开 >> bioskin GmbH Hamburg, Germany 收起 <<
NCT03058744 Psoriasis Phase 1 Completed - United States, California ... 展开 >> Valeant Site 12 Anaheim, California, United States, 92801 Valeant Site 05 Encino, California, United States, 91436 Valeant Site 01 San Diego, California, United States, 92093 Valeant Site 07 Santa Rosa, California, United States, 95401 United States, Florida Valeant Site 10 Orange Park, Florida, United States, 32065 Valeant Site 09 Sanford, Florida, United States, 32771 United States, Georgia Valeant Site 08 Atlanta, Georgia, United States, 30301 United States, Indiana Valeant Site 04 Plainfield, Indiana, United States, 46168 United States, New York Valeant Site 06 New York, New York, United States, 10001 United States, Pennsylvania Valeant Site 11 Philadelphia, Pennsylvania, United States, 19019 United States, Texas Valeant Site 03 Austin, Texas, United States, 73301 Valeant Site 02 Katy, Texas, United States, 77449 收起 <<
NCT01166646 Plaque Psoriasis Phase 2 Completed - United States, California ... 展开 >> Therapeutics Clinical Research San Diego, California, United States, 92123 United States, Michigan Michigan Center for Skin Care Research (dba Skin Care Research) Clinton Township, Michigan, United States, 48038 Somerset Skin Centre Troy, Michigan, United States, 48084 United States, North Carolina Dermatology, Laser & Vein Specialists of the Carolinas PLLC Charlotte, North Carolina, United States, 28207 United States, Texas DermResearch Inc. Austin, Texas, United States, 78759 收起 <<

Clobetasol propionate 参考文献

[1]Hull C, McKeough M, et al. Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient-initiated, double-blind, placebo-controlled pilot trial. J Eur Acad Dermatol Venereol. 2009 Mar;23(3):263-7.

[2]Feldman SR, Yentzer BA. Topical clobetasol propionate in the treatment of psoriasis: a review of newer formulations. Am J Clin Dermatol. 2009;10(6):397-406

[3]Pels R, Sterry W, Lademann J. Clobetasol propionate--where, when, why? Drugs Today (Barc). 2008 Jul;44(7):547-57

[4]Zeigler M, Chi Y, Tumas DB, Bodary S, Tang H, Varani J. Anti-CD11a ameliorates disease in the human psoriatic skin-SCID mouse transplant model: comparison of antibody to CD11a with Cyclosporin A and clobetasol propionate. Lab Invest. 2001 Sep;81(9):1253-61

[5]Menter MA, Caveney SW, Gottschalk RW. Impact of clobetasol propionate 0.05% spray on health-related quality of life in patients with plaque psoriasis. J Drugs Dermatol. 2012 Nov;11(11):1348-54

Clobetasol propionate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.14mL

0.43mL

0.21mL

10.71mL

2.14mL

1.07mL

21.41mL

4.28mL

2.14mL

Clobetasol propionate 技术信息

CAS号25122-46-7
分子式C25H32ClFO5
分子量 466.97
别名 CCl-4725;CGP9555;Clobetasol 17-Propionate
运输蓝冰
存储条件

In solvent -20°C:1个月-80°C:12个月

Pure form Keep in dark place,Sealed in dry,2-8°C
溶解方案

DMSO: 105 mg/mL(224.85 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方

IP 2% DMSO+2% Tween80+40% PEG300+water 9 mg/mL clear

PO 0.5% CMC-Na 60 mg/mL suspension

Tags: Clobetasol propionate | 25122-46-7 | Cytochrome P450 | CYPs | CYP3A5 Inhibitor | Metabolic Enzyme/Protease | Cytochrome P450 | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Clobetasol propionate 纯度/质量文件 | Clobetasol propionate 生物活性 | Clobetasol propionate 临床数据 | Clobetasol propionate 参考文献 | Clobetasol propionate 实验方案 | Clobetasol propionate 技术信息

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