Clobetasol propionate
产品说明书
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同义名 : | CCl-4725;CGP9555;Clobetasol 17-Propionate |
| CAS号 : | 25122-46-7 | |
| 货号 : | A505172 | |
| 分子式 : | C25H32ClFO5 | |
| 纯度 : | 98% | |
| 分子量 : | 466.97 | |
| MDL号 : | MFCD00058499 | |
| 存储条件： |
Pure form Keep in dark place,Sealed in dry,2-8°C In solvent -20°C:1个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(224.85 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
IP 2% DMSO+2% Tween80+40% PEG300+water 9 mg/mL clear PO 0.5% CMC-Na 60 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Clobetasol propionate is a corticosteroid[2]. Clobetasol propionate is the most potent of all topical steroids. It is successfully applied in the treatment of various skin diseases such as atopic dermatitis, psoriasis and vulvar lichen sclerosus. Clobetasol propionate exerts anti-inflammatory, immunosuppressive and antimitotic effects influencing the growth, differentiation and function of various cells and inhibiting cytokine production[3]. Clobetasol propionate (applied topically; daily for 14 days) reduces the epidermal thickness of both normal and psoriatic skin in human psoriatic skin-SCID mouse transplant model topical application[4]. When compared with calcipotriene/betamethasone dipropionate ointment, clobetasol propionate 0.05% spray produced greater rates of lesion clearance and similar improvement in QOL scores after 2 or 4 weeks of treatment. Clobetasol propionate 0.05% spray is an efficacious and safe treatment for plaque psoriasis and produces significant improvement in QOL for affected patients[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00544687 | Healthy | Phase 1 | Completed | - | Germany ... 展开 >> bioskin GmbH Hamburg, Germany 收起 << |
| NCT03058744 | Psoriasis | Phase 1 | Completed | - | United States, California ... 展开 >> Valeant Site 12 Anaheim, California, United States, 92801 Valeant Site 05 Encino, California, United States, 91436 Valeant Site 01 San Diego, California, United States, 92093 Valeant Site 07 Santa Rosa, California, United States, 95401 United States, Florida Valeant Site 10 Orange Park, Florida, United States, 32065 Valeant Site 09 Sanford, Florida, United States, 32771 United States, Georgia Valeant Site 08 Atlanta, Georgia, United States, 30301 United States, Indiana Valeant Site 04 Plainfield, Indiana, United States, 46168 United States, New York Valeant Site 06 New York, New York, United States, 10001 United States, Pennsylvania Valeant Site 11 Philadelphia, Pennsylvania, United States, 19019 United States, Texas Valeant Site 03 Austin, Texas, United States, 73301 Valeant Site 02 Katy, Texas, United States, 77449 收起 << |
| NCT01166646 | Plaque Psoriasis | Phase 2 | Completed | - | United States, California ... 展开 >> Therapeutics Clinical Research San Diego, California, United States, 92123 United States, Michigan Michigan Center for Skin Care Research (dba Skin Care Research) Clinton Township, Michigan, United States, 48038 Somerset Skin Centre Troy, Michigan, United States, 48084 United States, North Carolina Dermatology, Laser & Vein Specialists of the Carolinas PLLC Charlotte, North Carolina, United States, 28207 United States, Texas DermResearch Inc. Austin, Texas, United States, 78759 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.14mL 0.43mL 0.21mL |
10.71mL 2.14mL 1.07mL |
21.41mL 4.28mL 2.14mL |
| 参考文献 |
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