Cortexolone 17 alpha-propionate is a topical and peripherally selective androgen antagonist, which is used in treatment of acne and androgenic alopecia.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Androgens are C-19 steroids that provide major regulatory influences on male reproductive function[2].
Cortexolone 17 alpha-propionate is a topical and peripherally selective androgen antagonist, which is used in treatment of acne and androgenic alopecia[3]. Clascoterone 1% cream was very well tolerated, and was significantly better than placebo regarding TLC, ILC and ASI, and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters[4]. In vitro studies showed that clascoterone binds to androgen receptors with high affinity and inhibits DHT-stimulated signaling. Clascoterone dose-dependently inhibited DHT-induced lipid synthesis and infammatory cytokine production in human primary sebocytes[5]. In hair follicle dermal papilla cells, clascoterone selectively inhibited androgen receptor-regulated pathways that impede hair follicle growth, without affecting the production and secretion of pro-follicle growth factors[6]. Clascoterone cream did not afect the pharmacokinetics of drugs metabolized by CYP 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1 or 3A4 to a clinically meaningful extent[7]
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