货号:A771467 同义名: 5,7-Dihydroxyflavone;5,7-DHF
Chrysin, an analog of apigenin, demonstrates inhibition of aromatase and the phosphorylation of PLCY2 and PKC activities. It can be isolated from the blue passion flower (passiflora caerulea) with anti-inflammatory and anti-thrombotic activities etc..
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
产品名称 | Aromatase ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Obacunone |
+
Aromatase, IC50: 28.4 μM |
Nrf2 | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Chrysin, found in passion flowers, honey, and propolis, acts as a potential therapeutic and preventive agent against various human cancers, including ovarian cancer. It inhibits ovarian cancer cell proliferation and induces cell death by increasing ROS production, cytoplasmic Ca2+ levels, and inducing loss of mitochondrial membrane potential. Chrysin activates both MAPK and PI3K/AKT pathways, suppresses tumor growth by regulating Wnt and NF-κB signaling, and stimulates phosphorylation of AKT and P70S6K proteins[1]. |
体外研究 | Chrysin, found in passion flowers, honey, and propolis, acts as a potential therapeutic and preventive agent against various human cancers, including ovarian cancer. It inhibits ovarian cancer cell proliferation and induces cell death by increasing ROS production, cytoplasmic Ca2+ levels, and inducing loss of mitochondrial membrane potential. Chrysin activates both MAPK and PI3K/AKT pathways, suppresses tumor growth by regulating Wnt and NF-κB signaling, and stimulates phosphorylation of AKT and P70S6K proteins[1]. |
Dose | Mice: 0.6 mg/kg - 10 mg/kg[6] (i.p.), 50 mg/kg[7] (I.p.) Rat: 25 mg/kg - 100 mg/kg[8] (p.o.), 3 mg/kg - 30 mg/kg[9] (p.o.) |
Administration | i.p., p.o. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.93mL 0.79mL 0.39mL |
19.67mL 3.93mL 1.97mL |
39.33mL 7.87mL 3.93mL |
CAS号 | 480-40-0 |
分子式 | C15H10O4 |
分子量 | 254.238 |
别名 | 5,7-Dihydroxyflavone;5,7-DHF;Galangin flavanone.;NP005901;NSC 407436 |
运输 | 蓝冰 |
存储条件 |
粉末 Keep in dark place,Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(413 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |
IP 2% DMSO+2% Tween80+30% PEG300+water 2 mg/mL clear PO 0.5% CMC-Na 46 mg/mL suspension |