Chlortetracycline HCl is the first tetracycline to be identified, which can inhibit protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit and is more effective against Gram-positive bacteria.
Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes[3]. The combined 12.5 mg tiamulin hf/37.5 mg with chlortetracycline hydrochloride (hcl) /kg BW resulted in a significant reduction of the severity of clinical respiratory disease post treatment and a significant reduction of the M. gallisepticum numbers in the respiratory tract[4]. The calves receiving chlortetracycline hydrochloride were less affected by the enteric and respiratory disease outbreak[5]. Non-ionic tensides were found to enhance liberation of chlorotetracycline hydrochloride from lipophilic ointment bases, while liberation of this antibiotic from hydrophilic ointment bases proved to be depressed[6].
United States, Kentucky
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University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
United States, Kentucky
... 展开 >>
University of Louisville
Recruiting
Louisville, Kentucky, United States, 40202
Contact: Julio A Ramirez, MD 502-852-1148 jarami01@louisville.edu
Contact: David Seligson, MD 502-852-0923 d0seli01@louisville.edu
Sub-Investigator: Forest Arnold, DO
Sub-Investigator: Timothy Wiemkwn, PhD
Sub-Investigator: Robert Kelley, PhD
Sub-Investigator: James Summersgill, PhD
Sub-Investigator: Ruth Carrico, PhD
Sub-Investigator: Julie Harting, PharmD
Sub-Investigator: Paula Peyrani, MD
Principal Investigator: David Seligson, MD
Sub-Investigator: Craig Roberts, MD
Principal Investigator: Julio Ramirez, MD 收起 <<
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