产品说明书

Chlortetracycline HCI

Print
Chemical Structure| 64-72-2 同义名 : 盐酸金霉素 ;7-Chlorotetracycline hydrochloride;NSC 13252;Aureomycin monohydrochloride;7-Chlorotetracycline HCl;Chlortetracycline HCl
CAS号 : 64-72-2
货号 : A149086
分子式 : C22H24Cl2N2O8
纯度 : 95% (CTC HCl+TC HCl)
分子量 : 515.34
MDL号 : MFCD26142699
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Chlortetracycline hydrochloride is a specific and potent calcium ionophore antibiotic, inhibits binding of aminoacyl-tRNA to ribosomes[3]. The combined 12.5 mg tiamulin hf/37.5 mg with chlortetracycline hydrochloride (hcl) /kg BW resulted in a significant reduction of the severity of clinical respiratory disease post treatment and a significant reduction of the M. gallisepticum numbers in the respiratory tract[4]. The calves receiving chlortetracycline hydrochloride were less affected by the enteric and respiratory disease outbreak[5]. Non-ionic tensides were found to enhance liberation of chlorotetracycline hydrochloride from lipophilic ointment bases, while liberation of this antibiotic from hydrophilic ointment bases proved to be depressed[6].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02099240 Osteomyelitis Early Phase 1 Recruiting September 2019 United States, Kentucky ... 展开 >> University of Louisville Recruiting Louisville, Kentucky, United States, 40202 Contact: Julio A Ramirez, MD    502-852-1148    jarami01@louisville.edu    Contact: David Seligson, MD    502-852-0923    d0seli01@louisville.edu    Sub-Investigator: Forest Arnold, DO          Sub-Investigator: Timothy Wiemkwn, PhD          Sub-Investigator: Robert Kelley, PhD          Sub-Investigator: James Summersgill, PhD          Sub-Investigator: Ruth Carrico, PhD          Sub-Investigator: Julie Harting, PharmD          Sub-Investigator: Paula Peyrani, MD          Principal Investigator: David Seligson, MD          Sub-Investigator: Craig Roberts, MD          Principal Investigator: Julio Ramirez, MD 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.94mL

0.39mL

0.19mL

9.70mL

1.94mL

0.97mL

19.40mL

3.88mL

1.94mL
参考文献

[1]Pulicharla R, Das RK, et al. Toxicity of chlortetracycline and its metal complexes to model microorganisms in wastewater sludge. Sci Total Environ. 2015 Nov 1;532:669-75.

[2]Nelson ML, Levy SB. The history of the tetracyclines. Ann N Y Acad Sci. 2011 Dec;1241:17-32.

[3]Saling PM, Storey BT. Mouse gamete interactions during fertilization in vitro. Chlortetracycline as a fluorescent probe for the mouse sperm acrosome reaction. J Cell Biol. 1979 Dec;83(3):544-55.

[4]Garmyn A, Vereecken M, Degussem K, Depondt W, Haesebrouck F, Martel A. Efficacy of tiamulin alone or in combination with chlortetracycline against experimental Mycoplasma gallisepticum infection in chickens. Poult Sci. 2017 Sep 1;96(9):3367-3374.

[5]Braidwood JC, Henry NW. Clinical efficacy of chlortetracycline hydrochloride administered in milk replacer to calves. Vet Rec. 1990 Sep 22;127(12):297-301.

[6]Gadomska-Nowak M, Wojdak H, Godlewska J, Pasich J. Badania dostepności farmaceutycznej chlorowodorku chlorotetracykliny w wybranych podłozach maściowych [Studies on the pharmaceutical availability of chlortetracycline hydrochloride in selected ointment bases]. Acta Pol Pharm. 1989;46(1):70-3.