Cholecystokinin octapeptide (cholecystokinin-8) is found in the peripheral tissue and central nervous system (CNS). It is becoming clear that cholecystokinin-8 sulphate may function as a neurotransmitter or neuromodulator in the CNS. Thus, cholecystokinin-8 sulphate is released from synaptic vesicles in a calcium-dependent manner, binds to specific high affinity cholecystokinin receptors and exerts primarily excitatory effect on CNS neurons. One potential role that has been proposed for cholecystokinin is the modulation of central opiate nociceptive mechanism. Cholecystokinin receptors are generally divided into two classes, cholecystokinin-A (alimentary) and cholecystokin- in-B (brain)[3]. Caerulein is a decapeptide isolated from frog skin, which has been shown to possess the same biological and pharmacological activities as cholecystokinin-8[3]. Ceruletide in supramaximal but not in physiological doses activated NF-kappaB/Rel in vitro. This activation might induce a self-defending genetic program before the onset of cellular injury, which might prevent higher degrees of damage of pancreatic acinar cells after secretagogue hyperstimulation[4]. Ceruletide serum bile acid (SBA) stimulation circumvented exogenous and endogenous influences associated with postprandial (PP) SBA stimulation. Ceruletide SBA stimulation might perform as well as PP SBA stimulation in dogs with portosystemic shunt (PSS) and be more sensitive for the detection of hepatic dysfunction in dogs with upper respiratory disease (URD)[5]. Ceruletide (0.4-0.5 mcg/kg, i.v.; 3-4 mcg/kg, s.c.) resulted in emesis and evacuation of the bowel in the intact conscious dog, and recovery was complete 15 - 30 min after i. v. administration and 2 - 4h after s.c. administration. Ceruletide (5 - 15 ng/kg, i.v.) showed a marked spasmogenic effect on the pylorus of rats. Ceruletide also reduced blood pressure in anesthetized dogs[6].
United States, California
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San Francisco Veterans Affairs Medical Center. University of California
Not yet recruiting
San Francisco, California, United States, 94121
Contact endoresection@me.com
Principal Investigator: Tonya Kaltenbach
United States, North Carolina
University of North Carolina
Not yet recruiting
Chapel Hill, North Carolina, United States, 27599
Contact mcgills@email.unc.edu
Principal Investigator: Sarah McGill
Japan
National Cancer Center
Not yet recruiting
Tokyo, Japan, 104-0045
Contact tasakamo529@gmail.com
Principal Investigator: Taku Sakamoto
Spain
Hospital Clínico Universitario Lozano Blesa
Not yet recruiting
Zaragoza, Aragón, Spain, 50009
Contact angel.ferrandez@telefonica.net
Principal Investigator: Ángel Ferrández
Hospital Universitari Germans Trias i Pujol (Can Ruti)
Not yet recruiting
Badalona, Cataluña, Spain, 08916
Contact hugoikuo@gmail.com
Principal Investigator: Hugo Uchima
Hospital Clínic de Barcelona
Not yet recruiting
Barcelona, Cataluña, Spain, 08036
Contact MPELLISE@clinic.cat
Principal Investigator: Maria Pellisé
Sub-Investigator: Miriam Cuatrecasas
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Not yet recruiting
Barcelona, Cataluña, Spain, 08036
Contact JCAMPS@clinic.cat
Sub-Investigator: Jordi Camps
Althaia. Xarxa Assistencial Universitària de Manresa
Not yet recruiting
Manresa, Cataluña, Spain, 08243
Contact orosinol@althaia.cat
Sub-Investigator: Òria Rosiñol
Hospital Universitario y Politécnico de La Fe
Not yet recruiting
Valencia, Comunidad Valenciana, Spain, 46009
Contact mbustamantebalen@gmail.com
Principal Investigator: Marco Bustamante
Complejo Hospitalario de Navarra
Not yet recruiting
Pamplona, Navarra, Spain, 31008
Contact edualbeniz@hotmail.com
Principal Investigator: Eduardo Albéniz
Hospital Ramón y Cajal
Not yet recruiting
Madrid, Spain, 28034
Contact enrodesan@gmail.com
Principal Investigator: Enrique Rodríguez
Hospital 12 de Octubre
Not yet recruiting
Madrid, Spain, 28041
Contact josecarlos.marin@salud.madrid.org
Principal Investigator: José Carlos Marín 收起 <<
United States, California
... 展开 >>
San Francisco Veterans Affairs Medical Center. University of California
Not yet recruiting
San Francisco, California, United States, 94121
Contact endoresection@me.com
Principal Investigator: Tonya Kaltenbach
United States, North Carolina
University of North Carolina
Not yet recruiting
Chapel Hill, North Carolina, United States, 27599
Contact mcgills@email.unc.edu
Principal Investigator: Sarah McGill
Japan
National Cancer Center
Not yet recruiting
Tokyo, Japan, 104-0045
Contact tasakamo529@gmail.com
Principal Investigator: Taku Sakamoto
Spain
Hospital Clínico Universitario Lozano Blesa
Not yet recruiting
Zaragoza, Aragón, Spain, 50009
Contact angel.ferrandez@telefonica.net
Principal Investigator: Ángel Ferrández
Hospital Universitari Germans Trias i Pujol (Can Ruti)
Not yet recruiting
Badalona, Cataluña, Spain, 08916
Contact hugoikuo@gmail.com
Principal Investigator: Hugo Uchima
Hospital Clínic de Barcelona
Not yet recruiting
Barcelona, Cataluña, Spain, 08036
Contact MPELLISE@clinic.cat
Principal Investigator: Maria Pellisé
Sub-Investigator: Miriam Cuatrecasas
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Not yet recruiting
Barcelona, Cataluña, Spain, 08036
Contact JCAMPS@clinic.cat
Sub-Investigator: Jordi Camps
Althaia. Xarxa Assistencial Universitària de Manresa
Not yet recruiting
Manresa, Cataluña, Spain, 08243
Contact orosinol@althaia.cat
Sub-Investigator: Òria Rosiñol
Hospital Universitario y Politécnico de La Fe
Not yet recruiting
Valencia, Comunidad Valenciana, Spain, 46009
Contact mbustamantebalen@gmail.com
Principal Investigator: Marco Bustamante
Complejo Hospitalario de Navarra
Not yet recruiting
Pamplona, Navarra, Spain, 31008
Contact edualbeniz@hotmail.com
Principal Investigator: Eduardo Albéniz
Hospital Ramón y Cajal
Not yet recruiting
Madrid, Spain, 28034
Contact enrodesan@gmail.com
Principal Investigator: Enrique Rodríguez
Hospital 12 de Octubre
Not yet recruiting
Madrid, Spain, 28041
Contact josecarlos.marin@salud.madrid.org
Principal Investigator: José Carlos Marín 收起 <<
Malaysia
... 展开 >> University of Malaya Medical Centre
Recruiting
Kuala Lumpur, Wilayah Persekutuan, Malaysia, 59100
Contact: Pei Chien Tah 0163091880 pctah@ummc.edu.my
Sub-Investigator: Mohd Shahnaz Bin Hasan
Sub-Investigator: Vineya Rai Hakumat Rai
Sub-Investigator: Bee Koon Poh
Sub-Investigator: Mohd Basri Bin Mat Nor
Sub-Investigator: Hazreen Bin Abdul Majid
Sub-Investigator: Chee Cheong Kee
Sub-Investigator: Mazuin Kamarul Zaman 收起 <<
Austria
... 展开 >> Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine
Not yet recruiting
Vienna, Austria
Contact: Michael Hiesmayr, MD michael.hiesmayr@meduniwien.ac.at
Belgium
Department of Intensive Care, Vrije Universiteit Brussel
Not yet recruiting
Brussels, Belgium
Contact: Elisabeth DeWaele, MD, PhD Elisabeth.DeWaele@uzbrussel.be
Israel
Critical Care Medicine, Institute for Nutrition Research, Rabin Medical Center, Beilison Hospital
Not yet recruiting
Petah Tikva, Israel, 49100
Contact: Pierre Singer, MD psinger@clalit.org.il
Norway
Department of Anaesthesiology and Intensive Care Haukeland University Hospital
Not yet recruiting
Bergen, Norway, 5021
Contact: Anne Berit Guttormsen, MD, PhD anne.guttormsen@helse-bergen.no
Sweden
Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital
Not yet recruiting
Huddinge, Sweden
Contact: Jan Wernerman, MD,PhD jan.wernerman@karolinska.se
Switzerland
Service of Intensive Care, Geneva University Hospital
Recruiting
Geneva, Switzerland, 1211
Contact: Claudia-Paula Heidegger, MD claudia-paula.heidegger@hcuge.ch
Contact: Severine Graf Severine.Graf@hcuge.ch
Adult Intensive care, Lausanne University Hospital
Not yet recruiting
Lausanne, Switzerland, 1011
Contact: Mette M Berger, MD, PhD Mette.Berger@chuv.ch 收起 <<
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