货号:A602084 同义名: NSC 318735;Baccatin III
Cephalomannine, a natural product isolated and purified from the barks of Cephalotaxus sinensis (Rehd. et Wils.) Li, is a taxol derivative with antitumor, antiproliferative properties.
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
规格 | 价格 | 会员价 | 库存 | 数量 | |||
---|---|---|---|---|---|---|---|
{[ item.pr_size ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
描述 | Cephalomannine is an alkaloidal analog of Paclitaxel, derived from various Cephalotaxus species. It functions as an orally active anti-tumor agent and is employed in chemotherapy for cancer research[1][2][3]. |
体内研究 | In vivo, Cephalomannine administered at a dose of 0.4 mg/kg through intraperitoneal injection over a span of 10 days significantly curtails the growth of lung cancer cells in a nude mouse xenograft model, all while exhibiting no apparent side effects[3]. The mechanism by which Cephalomannine operates includes disrupting the interaction between APEX1 and HIF-1α through competitive binding with APEX1, highlighting its potential therapeutic action in tumor environments, particularly under hypoxic conditions[3]. |
体外研究 | In cellular studies, Cephalomannine has shown significant anti-proliferative effects on lung cancer cell lines such as H460, A549, and H1299 under normal oxygen conditions, with IC50 values of 0.18, 0.20, and 0.37 μM respectively. Furthermore, Cephalomannine effectively reduces cell viability under hypoxic conditions as well[3]. Cephalomannine impacts the viability, reactive oxygen species (ROS) production, intracellular pH, migration of hypoxic lung cancer cells, and angiogenesis in hypoxic human umbilical vein endothelial cells (HUVECs). This is achieved through its inhibition of the interaction between APEX1 and HIF-1α in H460 and A549 cell lines over time periods of 0, 12, and 24 hours[3]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.20mL 0.24mL 0.12mL |
6.01mL 1.20mL 0.60mL |
12.02mL 2.40mL 1.20mL |
CAS号 | 71610-00-9 |
分子式 | C45H53NO14 |
分子量 | 831.9 |
别名 | NSC 318735;Baccatin III;Cephalomannine, taxol B. |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(126.22 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |