There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Angiotensin-converting enzyme (ACE) is helpful in controling blood pressure and converting the hormone angiotensin I to be active. Captopril is an ACE inhibitor with IC50 of 6 nM which can reduce the risk of doubling the serum creatinine concentration by almost 50% in patients and also be helpful in renal dysfunction therapy and blood pressure reduction. Besides, Captopril can also be used for the treatment of diabetic nephropathy and left ventricular dysfunction. This drug can reach to peak hypotensive effect in 1 - 1.5 hrs with about 30% protein binding ratio and serum half-life of 2 hrs[1]. LNM35 cells treated with captopril of concentrations from 0.01 to 10 mM for 24 hrs showed inhibitory impact on the cell viability at all these concentrations, the differences were significant in the concentrations of 0.1, 1 and 10 mM. While LNM35 cells treated with captopril of concentrations from 0.001 to 10 mM in FBS buffer for 24 - 48 hrs demonstrated induction of cell apoptosis from 2.5% for control group to 9% and 15.5% for captopril-treated cells, respectively. The higher of the captopril concentrations, the more of the apoptosis induction. NMRI female nude mice with about 100 mm3 tumors were treated with 2.8 mg captopril per mouse and the results showed that the human tumor xenografts growth was significantly reduced by 52% and 58% at the 18 and 21 days respectively. Furthermore, the mean lymph node weight was 63.5 mg in the captopril-treated group, smaller than that in the control group (127mg). Captopril also decreased the tumor cell proliferation by assessing the levels of the nuclear antigen Ki-67 in Ki-67-positive cells[2].
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