There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
CYM-5520, as a selective and allosteric agonist for S1PR2, exhibits an EC50 of 480 nM. It is inactive on S1PR1, S1PR3, S1PR4, and S1PR5 receptors. CYM-5520 has the ability to co-bind with S1P at the S1PR2 receptor site. It is applicable in the study of osteoporosis[1][2]. CYM-5520, with an EC50 of 1.6 μM, fully activates the wild type S1PR2. In contrast, cells with the triple mutant S1PR2 do not show increased luciferase activity when stimulated with S1P, but CYM-5520 remains an effective agonist with an EC50 of 1.5 μM[1].
CYM-5520 动物研究
Animal study
Treatment with CYM-5520 at a dosage of 10 mg/kg, administered intraperitoneally over a period of five days each week for six weeks, has been shown to significantly enhance the mass of long and vertebral bones in osteopenic ovariectomized mice. Additionally, CYM-5520 leads to an increase in the number of osteoblasts, the osteoid surface area, and the activity of alkaline phosphatase. There is also a noted rise in the plasma levels of procollagen I C-terminal propeptide, an indicator of osteoanabolic activity[2].
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