CYM-5520 | S1PR2 Agonist | AmBeed-信号通路专用抑制剂

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CYM-5520 {[allProObj[0].p_purity_real_show]}

货号：A1209636

CYM-5520是一种选择性 S1PR2 受体激动剂，显示出在骨质疏松症研究中的潜力。它通过调节骨代谢，具有改善骨密度和强度的作用。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CYM-5520 化学结构
CAS号：1449747-00-5

CYM-5520 3D分子结构
CAS号：1449747-00-5

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CYM-5520 纯度/质量文件产品仅供科研

货号：A1209636 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JACS Au, 2024. Ambeed. [ A148168 ]; • JMC, 2024. Ambeed. [ A187643 ]; • JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]; • Biomacromolecules, 2024. Ambeed. [ A110759 ]; • Biomacromolecules, 2024. Ambeed. [ A203543 ]; 更多 >

CYM-5520 生物活性

描述

CYM-5520, as a selective and allosteric agonist for S1PR2, exhibits an EC50 of 480 nM. It is inactive on S1PR1, S1PR3, S1PR4, and S1PR5 receptors. CYM-5520 has the ability to co-bind with S1P at the S1PR2 receptor site. It is applicable in the study of osteoporosis^[1]^[2]. CYM-5520, with an EC50 of 1.6 μM, fully activates the wild type S1PR2. In contrast, cells with the triple mutant S1PR2 do not show increased luciferase activity when stimulated with S1P, but CYM-5520 remains an effective agonist with an EC50 of 1.5 μM^[1].

CYM-5520 动物研究

Animal study

Treatment with CYM-5520 at a dosage of 10 mg/kg, administered intraperitoneally over a period of five days each week for six weeks, has been shown to significantly enhance the mass of long and vertebral bones in osteopenic ovariectomized mice. Additionally, CYM-5520 leads to an increase in the number of osteoblasts, the osteoid surface area, and the activity of alkaline phosphatase. There is also a noted rise in the plasma levels of procollagen I C-terminal propeptide, an indicator of osteoanabolic activity^[2].

CYM-5520 参考文献

[1]Hideo Satsu, et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg Med Chem. 2013 Sep 1;21(17):5373-82.

[2]Sarah Weske, et al. Agonist-induced activation of the S1P receptor 2 constitutes a novel osteoanabolic therapy for the treatment of osteoporosis in mice. Bone. 2019 Aug;125:1-7.

CYM-5520 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.90mL

0.58mL

0.29mL

14.48mL

2.90mL

1.45mL

28.95mL

5.79mL

2.90mL

CYM-5520 技术信息

CAS号	1449747-00-5
分子式	C₂₁H₁₉N₃O₂
分子量	345.394

别名
运输	蓝冰

存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 50 mg/mL(144.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

浓度

体积

分子量

质量

CYM-5520 {[allProObj[0].p_purity_real_show]}

CYM-5520 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

CYM-5520 质控信息

CYM-5520 生物活性

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CYM-5520 参考文献

CYM-5520 实验方案

CYM-5520 技术信息

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CYM-5520 {[allProObj[0].p_purity_real_show]}

CYM-5520 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

CYM-5520 质控信息

CYM-5520 生物活性

CYM-5520 动物研究

CYM-5520 参考文献

CYM-5520 实验方案

CYM-5520 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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CYM-5520 纯度/质量文件产品仅供科研