There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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快速发货 顺丰冷链运输,1-2 天到达
品质保证
技术支持
免费溶解
描述 | CYM-5520, as a selective and allosteric agonist for S1PR2, exhibits an EC50 of 480 nM. It is inactive on S1PR1, S1PR3, S1PR4, and S1PR5 receptors. CYM-5520 has the ability to co-bind with S1P at the S1PR2 receptor site. It is applicable in the study of osteoporosis[1][2]. CYM-5520, with an EC50 of 1.6 μM, fully activates the wild type S1PR2. In contrast, cells with the triple mutant S1PR2 do not show increased luciferase activity when stimulated with S1P, but CYM-5520 remains an effective agonist with an EC50 of 1.5 μM[1]. |
Animal study | Treatment with CYM-5520 at a dosage of 10 mg/kg, administered intraperitoneally over a period of five days each week for six weeks, has been shown to significantly enhance the mass of long and vertebral bones in osteopenic ovariectomized mice. Additionally, CYM-5520 leads to an increase in the number of osteoblasts, the osteoid surface area, and the activity of alkaline phosphatase. There is also a noted rise in the plasma levels of procollagen I C-terminal propeptide, an indicator of osteoanabolic activity[2]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.90mL 0.58mL 0.29mL |
14.48mL 2.90mL 1.45mL |
28.95mL 5.79mL 2.90mL |
CAS号 | 1449747-00-5 |
分子式 | C21H19N3O2 |
分子量 | 345.394 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 50 mg/mL(144.76 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |