产品说明书

CYM-5520

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Chemical Structure| 1449747-00-5 同义名 : -
CAS号 : 1449747-00-5
货号 : A1209636
分子式 : C21H19N3O2
纯度 : 97%
分子量 : 345.394
MDL号 : MFCD28100815
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(144.76 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CYM-5520, as a selective and allosteric agonist for S1PR2, exhibits an EC50 of 480 nM. It is inactive on S1PR1, S1PR3, S1PR4, and S1PR5 receptors. CYM-5520 has the ability to co-bind with S1P at the S1PR2 receptor site. It is applicable in the study of osteoporosis[1][2]. CYM-5520, with an EC50 of 1.6 μM, fully activates the wild type S1PR2. In contrast, cells with the triple mutant S1PR2 do not show increased luciferase activity when stimulated with S1P, but CYM-5520 remains an effective agonist with an EC50 of 1.5 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.90mL

0.58mL

0.29mL

14.48mL

2.90mL

1.45mL

28.95mL

5.79mL

2.90mL
参考文献

[1]Hideo Satsu, et al. A sphingosine 1-phosphate receptor 2 selective allosteric agonist. Bioorg Med Chem. 2013 Sep 1;21(17):5373-82.

[2]Sarah Weske, et al. Agonist-induced activation of the S1P receptor 2 constitutes a novel osteoanabolic therapy for the treatment of osteoporosis in mice. Bone. 2019 Aug;125:1-7.