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CP-31398 2HCl {[allProObj[0].p_purity_real_show]}

货号:A675515 同义名: CP 31,398 (hydrochloride);CP-31398 Dihydrochloride Ambeed 开学季,买赠积分,赢豪礼

CP-31398 2HCl is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

CP-31398 2HCl 化学结构 CAS号:1217195-61-3
CP-31398 2HCl 化学结构
CAS号:1217195-61-3
CP-31398 2HCl 3D分子结构
CAS号:1217195-61-3
CP-31398 2HCl 化学结构 CAS号:1217195-61-3
CP-31398 2HCl 3D分子结构 CAS号:1217195-61-3
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CP-31398 2HCl 纯度/质量文件 产品仅供科研

货号:A675515 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 p53 其他靶点 纯度
Pifithrin-μ {[allProObj[0].p_purity_real_show]}
Pifithrin-α HBr {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

CP-31398 2HCl 生物活性

描述 The tumor suppressor p53 plays various functional roles in the cell by regulating multiple regulatory signals that ensure adequate temporal and spatial responses to cellular stress. p53 is usually kept inactive due to ubiquitination by a number of E3 ubiquitin ligases that target p53 for proteasomal degradation[3].CP-31398, a styrylquinazoline, emerges from a screen for therapeutic agents that restore the wild-type DNA-binding conformation of mutant p53 to suppress tumors in vivo.CC cells treated with CP-31398 or treated with sh-PAX2 inhibited proliferation, invasion, and migration but promoted apoptosis with decreased PAX2 expression. The EMT process in CC cells was also reversed after treatment with CP-31398 or sh-PAX2. Moreover, the tumor formation experiment in nude mice revealed the inhibitory activity of CP-31398 in CC tumor in nude mice by suppressing PAX2[4].CP-31398 induced growth retardation but the cytotoxic effects were irrelevant to p53 genotype. CP-31398 influenced expression of p53 and the downstream molecules in a cell-dependent manner, but constantly increased p21 expression at the transcriptional level with decreased YY1 expression[5].The EC cells treated with CP‑31398 or siRNA against MDM2 exhibited an increased apoptosis and a suppressed migration and invasion, corresponding to an increased expression of p53, p21, Bad, Bax, Cyt‑c and caspase‑3, as well as to a decreased expression of Bcl‑2, Cox‑2, MMP‑2 and MMP‑9[6].

CP-31398 2HCl 参考文献

[1]Fujiwara T, Morimoto K. A compound CP-31398 suppresses excitotoxicity-induced neurodegeneration. Biochem Biophys Res Commun. 2013 Oct 25;440(3):359-63.

[2]Johnson WD, Muzzio M, et al. Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs. Toxicology. 2011 Nov 18;289(2-3):141-50.

[3] Chuck C-K Chao. Mechanisms of p53 degradation. Clin Chim Acta. 2015 Jan 1;438:139-47.

[4]Ling Liu,et al. CP-31398 inhibits the progression of cervical cancer through reversing the epithelial mesenchymal transition via the downregulation of PAX2s. J Cell Physiol. 2019 Mar;234(3):2929-2942.

[5]Boya Zhong,et al. A p53-stabilizing agent, CP-31398, induces p21 expression with increased G2/M phase through the YY1 transcription factor in esophageal carcinoma defective of the p53 pathway. Am J Cancer Res. 2019 Jan 1;9(1):79-93. eCollection 2019.

[6] Ling Liu,et al. CP‑31398 attenuates endometrial cancer cell invasion, metastasis and resistance to apoptosis by downregulating MDM2 expression. Int J Oncol. 2019 Mar;54(3):942-954.

CP-31398 2HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.30mL

0.46mL

0.23mL

11.48mL

2.30mL

1.15mL

22.97mL

4.59mL

2.30mL

CP-31398 2HCl 技术信息

CAS号1217195-61-3
分子式C22H28Cl2N4O
分子量 435.39
别名 CP 31,398 (hydrochloride);CP-31398 Dihydrochloride
运输蓝冰
存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 190 mg/mL(436.39 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方
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