Bufalin a major digoxin-like immunoreactive component of the Chinese medicine Chan Su and has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro.
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HazMat fee for 500 gram (Estimated)
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Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively[3]. Bufalin caused significant cytotoxicity in NCI-H460 cells at a concentration as low as 1 μM. DNA condensation was observed in bufalin-treated cells in a dose-dependent manner. Bufalin injected intraperitoneally in a dose-dependent manner reduced tumor size in BALB/C nu/nu mice implanted with NCI-H460 cells. Bufalin injection did not produce significant drug-related toxicity in experimental animals except at a high dose (0.4 mg/kg)[4]. Bufalin-induced disruption of the SRC-1 (steroid receptor coactivator) isoform/ERβ (estrogen receptor) axis might induce apoptosis, pyroptosis and ERS (endoplasmic reticulum-stress) signaling in endometriotic lesions, causing the suppression of endometriosis[5]. Bufalin inhibits cell proliferation and migration of HCC (hepatocellular carcinoma) cells via APOBEC3F induced intestinal immune network for IgA production signaling pathway[6].
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