Bindarit | AF2838 | MCP/CCL Inhibitor | AmBeed-信号通路专用抑制剂

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宾达利 /Bindarit {[allProObj[0].p_purity_real_show]}

货号：A189075 同义名： AF2838;AF 2838

Bindarit, a CCL2, CCL7 and CCL8 inhibitor, is an anti-inflammatory agent.

Bindarit 化学结构
CAS号：130641-38-2

Bindarit 3D分子结构
CAS号：130641-38-2

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Bindarit 纯度/质量文件产品仅供科研

货号：A189075 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

CCR 亚型比较

产品名称	CCR ↓ ↑	纯度
Maraviroc	++ MIP-1β, IC50: 5.2 nM MIP-1α, IC50: 3.3 nM	99%+
DAPTA	+++ gp120 Bal-CCR5, IC50: 0.06 nM CM235-CCR5, IC50: 0.32 nM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Bindarit 生物活性

描述	Bindarit (AF2838) selectively inhibits monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, without affecting other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, and MIP-3/CCL23. It also exhibits anti-inflammatory properties^[1].
体内研究	Administered orally at 50 mg/kg daily for varying durations (4, 6, and 8 months) to NZB/W F1 female mice, Bindarit delays the onset of proteinuria and significantly protects against renal function impairment while completely preventing monocyte chemoattractant protein (MCP-1) up-regulation^[2].
体外研究	At concentrations of 100 µM and 300 µM, Bindarit significantly reduces platelet-derived growth factor-BB (PDGF-BB)-induced proliferation of rat vascular smooth muscle cells (VSMCs) by 27% and 42%, respectively, after 48 hours^[1].

Bindarit 动物研究

Dose	Rat: 12.5 mg/kg^[2] (p.o.), 200 mg/kg^[3] (p.o.)
Administration	p.o.

Bindarit 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01269242	Coronary Restenosis	Phase 2	Completed	-	Italy ... 展开 >> Fondazione S.Raffaele del Monte Tabor - UO Emodinamica e Cardiologia Interventistica Milan, Italy, 20132 收起 <<
NCT01109212	Diabetic Nephropathy	Phase 2	Completed	-	Italy ... 展开 >> The Mario Negri Institute for Pharmacological Research- Clinical Research Center for Rare Diseases Ranica, Bergamo, Italy, 24020 Azienda Ospedaliera di Treviglio-Caravaggio - Unità Operativa Malattie Metaboliche e Diabetologia Treviglio, Bergamo, Italy, 24047 Azienda Ospedaliera OO.RR. Bergamo - Unità Operativa Diabetologia Bergamo, Italy, 24128 IRCCS Fondazione Centro S. Raffaele del Monte Tabor- Unità Operativa Medicina Generale Milano, Italy, 20132 Ist. Patologia Medica e metodologia Clinica - Università di Sassari Sassari, Italy, 7100 Slovenia University Medical Center Dpt Endocrinology Diabetes and Metabolic Diseases- Diabetology Unit Ljubljana, Slovenia, 1000 收起 <<

Bindarit 参考文献

[1]Grassia, G., et al., The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice. Cardiovasc Res, 2009. 84(3): p. 485-93.

[2]Zoja C, Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease. Kidney Int. 1998 Mar;53(3):726-34.

Bindarit 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.08mL

0.62mL

0.31mL

15.41mL

3.08mL

1.54mL

30.83mL

6.17mL

3.08mL

Bindarit 技术信息

CAS号	130641-38-2
分子式	C₁₉H₂₀N₂O₃
分子量	324.374

别名	AF2838;AF 2838
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C

溶解度

DMSO: 45 mg/mL(138.73 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

IP 2% DMSO+2% Tween80+40% PEG300+water 7 mg/mL clear

PO 0.5% CMC-Na 38 mg/mL suspension

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01269242	Coronary Restenosis	Phase 2	Completed	-	Italy ... 展开 >> Fondazione S.Raffaele del Monte Tabor - UO Emodinamica e Cardiologia Interventistica Milan, Italy, 20132 收起 <<
NCT01109212	Diabetic Nephropathy	Phase 2	Completed	-	Italy ... 展开 >> The Mario Negri Institute for Pharmacological Research- Clinical Research Center for Rare Diseases Ranica, Bergamo, Italy, 24020 Azienda Ospedaliera di Treviglio-Caravaggio - Unità Operativa Malattie Metaboliche e Diabetologia Treviglio, Bergamo, Italy, 24047 Azienda Ospedaliera OO.RR. Bergamo - Unità Operativa Diabetologia Bergamo, Italy, 24128 IRCCS Fondazione Centro S. Raffaele del Monte Tabor- Unità Operativa Medicina Generale Milano, Italy, 20132 Ist. Patologia Medica e metodologia Clinica - Università di Sassari Sassari, Italy, 7100 Slovenia University Medical Center Dpt Endocrinology Diabetes and Metabolic Diseases- Diabetology Unit Ljubljana, Slovenia, 1000 收起 <<

宾达利 /Bindarit {[allProObj[0].p_purity_real_show]}

Bindarit 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Bindarit 质控信息

Bindarit 生物活性

Bindarit 动物研究

Bindarit 临床研究

Bindarit 参考文献

Bindarit 实验方案

Bindarit 技术信息

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宾达利 /Bindarit {[allProObj[0].p_purity_real_show]}

Bindarit 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Bindarit 质控信息

Bindarit 生物活性

Bindarit 动物研究

Bindarit 临床研究

Bindarit 参考文献

Bindarit 实验方案

Bindarit 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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Bindarit 纯度/质量文件产品仅供科研