Bergapten | 5-Methoxypsoralen;5-MOP;NSC 95437;Heraclin | 佛手苷内酯 | Plant Standard | P450

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佛手柑内酯 /Bergapten {[allProObj[0].p_purity_real_show]}

货号：A141454 同义名： 佛手苷内酯 / 5-Methoxypsoralen;5-MOP

5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation [psoralen plus UV (PUVA)] to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line.

Bergapten 化学结构
CAS号：484-20-8

Bergapten 3D分子结构
CAS号：484-20-8

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Bergapten 纯度/质量文件产品仅供科研

货号：A141454 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]; • JMC, 2024. Ambeed. [ A833302 , A475501 , A341986 , A356070 ]; • BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]; • J. Am. Soc. Mass Spectrom., 2024, 35(12): 3192-3202. Ambeed. [ A166127 , A902473 , A753371 , A961334 , A292945 , A230770 , A300620 , A1114580 , A1159765 , A206238 ]; • PloS One, 2024, 19(11): e0308060. Ambeed. [ A302917 ]; 更多 >

Bergapten 生物活性

描述

5-Methoxypsoralen (Bergapten) is a natural anti-inflammatory and anti-tumor agent isolated from bergamot essential oil, other citrus essential oils and grapefruit juice. 5-methoxypsoralen led to time-dependent as well as dose-dependent inhibitory effects on U-87MG human glioma cells. 5-Methoxypsoralen led to a substantial decrease of cell count along with distorted cell morphology. 5-methoxypsoralen also led to dose-dependent G2/M phase cell cycle arrest. 5-Methoxypsoralen-treated cells also exhibited altered cell ultrastructure with the appearance of autophagic vacuoles and the number of these vacuoles increased with increasing drug dose^[3]. 5-MOP (5-Methoxypsoralen) increased the activity of NAT (N-acetyltransferase) and also increased the further metabolism of AAF ( 2-acetylaminofluorene) at 24 h in the rat stomach. 5-MOP decreased the activity of NAT only at 72-h incubation in SC-M1 cells. The optimal concentrations of 5-MOP to induce decreased NAT activity in SC-M1 (human stomach) cells were 0.05 mM to 25 mM. In COLO 205 cells, there is decreased NAT activity at low doses of Bergapten (0.05 mM and 0.5 mM) and increased NAT activity at a high dose (50 mM)^[4]. In addition, DSG (diosgenin) and 5-MOP may improve insulin resistance through an ER-mediated PI3K/Akt activation pathway^[5].

Bergapten 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00533195	Atopic Dermatitis	Phase 3	Completed	-	Austria ... 展开 >> Medical University of Vienna; University Clinic of Dermatology; Division of Special and Environmental Dermatology Vienna, Austria, 1090 收起 <<
NCT00811005	Pustular Palmoplantar Psoriasi... 展开 >>s 收起 <<	Phase 3	Unknown	October 2010	Austria ... 展开 >> Medical University of Vienna; University Clinic of Dermatology; Division of Special and Environmental Dermatology Vienna, Austria, 1180 收起 <<

Bergapten 参考文献

[1]Panno ML, Giordano F, et al.Bergapten induces ER depletion in breast cancer cells through SMAD4-mediated ubiquitination. Breast Cancer Res Treat. 2012 Nov;136(2):443-55.

[2]Liu WX, Jia FL, et al. Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice. World J Gastroenterol. 2012 May 14;18(18):2197-202.

[3]Guo H, He Y, Bu C, Peng Z. Antitumor and apoptotic effects of 5-methoxypsoralen in U87MG human glioma cells and its effect on cell cycle, autophagy and PI3K/Akt signaling pathway. Arch Med Sci. 2019;15(6):1530-1538

[4]Lee YM, Wu TH. Effects of 5-methoxypsoralen (5-MOP) on arylamine N-acetyltransferase activity in the stomach and colon of rats and human stomach and colon tumor cell lines. In Vivo. 2005;19(6):1061-1069

[5]Fang K, Dong H, Jiang S, et al. Diosgenin and 5-Methoxypsoralen Ameliorate Insulin Resistance through ER-α/PI3K/Akt-Signaling Pathways in HepG2 Cells. Evid Based Complement Alternat Med. 2016;2016:7493694

Bergapten 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

4.63mL

0.93mL

0.46mL

23.13mL

4.63mL

2.31mL

46.26mL

9.25mL

4.63mL

Bergapten 技术信息

CAS号	484-20-8
分子式	C₁₂H₈O₄
分子量	216.19

别名	佛手苷内酯 ;5-Methoxypsoralen;5-MOP;NSC 95437;Heraclin
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature

溶解度

DMSO: 18 mg/mL(83.26 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

佛手柑内酯 /Bergapten {[allProObj[0].p_purity_real_show]}

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佛手柑内酯 /Bergapten {[allProObj[0].p_purity_real_show]}

Bergapten 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Bergapten 质控信息

Bergapten 生物活性

Bergapten 临床研究

Bergapten 参考文献

Bergapten 实验方案

Bergapten 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

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Bergapten 纯度/质量文件产品仅供科研