Benzyl Alcohol is a monoaromatic primary alcohol widely used as a solvent and as an intermediate in cosmetic formulations, pharmaceutical and flavor/fragrance industries.
Benzyl alcohol is an aromatic alcohol with a mild aromatic odor and acts as an inhibitor of the P450 enzyme. It modulates the Toll-Like Receptor 4, thereby reducing the inflammatory response associated with liver injury in mice[1].[2].[3].
体内研究
Furthermore, an intraperitoneal injection of Benzyl alcohol (270 mg/kg) can mitigate liver damage induced by acetaminophen over a duration of 0.5 to 24 hours[2].
体外研究
In MDCK cells, Benzyl alcohol (10-80 mM) affects cyclic AMP synthesis by increasing membrane fluidity in intact renal epithelial cells[1].
Additionally, Benzyl alcohol (0-46 mM, 48 h) protects against the hepatotoxic effects of acetaminophen (APAP) by inhibiting cytochrome P450 enzyme activity in mouse liver[2].
United States, New York
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Memorial Sloan Kettering
New York, New York, United States, 10065
United States, Ohio
Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44195 收起 <<
United States, New York
... 展开 >>
Memorial Sloan Kettering
New York, New York, United States, 10065
United States, Ohio
Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44195 收起 <<
United States, Maryland
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National Institutes of Health Clinical Center
Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov 收起 <<
United Kingdom
... 展开 >> St George's Vaccine Institute
London, England, United Kingdom, SW17 0RE
York Hospital
York, England, United Kingdom, YO31 7WA 收起 <<
United States, Arkansas
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Burke Pharmaceutical Research
Hot Springs, Arkansas, United States, 71913
United States, Florida
Lice Solutions Resource Network, Inc.
West Palm Beach, Florida, United States, 33407 收起 <<
United States, Idaho
... 展开 >>
Injury Care Medical Center
Recruiting
Boise, Idaho, United States, 83713
Contact: Jill L Heinz, MHS, CCRP 208-939-2100 ext 4 jill@injurycaremedical.com
Principal Investigator: Richard D Radnovich, DO 收起 <<
United States, Illinois
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Northwestern University Feinberg School of Medicine, Department of Dermatology
Chicago, Illinois, United States, 60611 收起 <<
Israel
... 展开 >> Tel Aviv Sourasky Medical Center
Recruiting
Tel Aviv, Israel, 64239
Contact: Shmuel Kivity, Prof. +972-3-697-3734 allergy@tasmc.health.gov.il
Contact: Tzipi Yemini +972-3-697-3734 zipiy@tasmc.health.gov.il
Principal Investigator: Shmuel Kivity, Prof. 收起 <<
United States, District of Col... 展开 >>umbia
Whitman Walker Clinic
Recruiting
Washington, District of Columbia, United States, 20009
Principal Investigator: Richard Elion, MD 收起 <<
Terminated(Halted by NICHD aft... 展开 >>er recommendation by DSMC to stop for futility) 收起 <<
-
United States, Alabama
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University of Alabama - Birmingham
Birmingham, Alabama, United States, 35429
United States, Illinois
Northwestern University-Prentice Hospital
Chicago, Illinois, United States, 60611
United States, Michigan
Dept of OB/GYN, Hutzel Hospital
Detroit, Michigan, United States, 48201
United States, New York
Columbia University-St. Luke's Hospital
New York City, New York, United States, 10032
United States, North Carolina
University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, United States, 27599
United States, Ohio
Case Western Reserve-Metrohealth
Cleveland, Ohio, United States, 44109
Ohio State University Hospital
Columbus, Ohio, United States, 43210
United States, Oregon
Oregon Health & Sciences University
Portland, Oregon, United States
United States, Pennsylvania
University of Pittsburgh-Magee Womens Hospital
Pittsburgh, Pennsylvania, United States, 15213
United States, Rhode Island
Brown University -Women and Infants Hospital
Providence, Rhode Island, United States, 02095
United States, Texas
Dept of OB/GYN, Southwestern Medical Center, University of Texas
Dallas, Texas, United States, 75235-9032
University of Texas Medical Branch - Galveston
Galveston, Texas, United States, 77555
University of Texas-Houston
Houston, Texas, United States
United States, Utah
University of Utah Medical Center
Salt Lake City, Utah, United States, 84132 收起 <<
Hungary
... 展开 >> Depts. Gynecology and Obstetrics and 3rd Dept of Internal Medicine
Recruiting
Budapest, Hungary, H1125
Contact: George Füst, Prof. 361-212-9351 fustge@kut.sote.hu
Principal Investigator: János Rigó, Prof.
Principal Investigator: Henriette Farkas, Prof. 收起 <<
United States, Massachusetts
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Beth Israel Deaconess - East Campus A0102 CRS
Boston, Massachusetts, United States, 02215
United States, Minnesota
University of Minnesota, ACTU
Minneapolis, Minnesota, United States
United States, New York
NY Univ. HIV/AIDS CRS
New York, New York, United States, 10016 收起 <<
United States, California
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Universal Biopharma Research Institute
Dinuba, California, United States, 93618
Axis Clinical Trials
Los Angeles, California, United States, 90036 收起 <<
Infant, Newborn
... 展开 >> Infant, Small for Gestational Age
Infant, Very Low Birth Weight
Infant, Premature
Bronchopulmonary Dysplasia 收起 <<
Phase 3
Recruiting
January 2025
United States, Alabama
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University of Alabama at Birmingham
Recruiting
Birmingham, Alabama, United States, 35233
Contact: Waldemar A. Carlo, MD
Principal Investigator: Waldemar A. Carlo, MD
United States, California
University of California - Los Angeles
Active, not recruiting
Los Angeles, California, United States, 90025
Stanford University
Recruiting
Palo Alto, California, United States, 94304
Contact: Krisa P. Van Meurs, MD
Principal Investigator: Krisa P. Van Meurs, MD
United States, Georgia
Emory University
Recruiting
Atlanta, Georgia, United States, 30303
Contact: David P Carlton, MD
Principal Investigator: David P Carlton, MD
United States, Indiana
Indiana University
Active, not recruiting
Indianapolis, Indiana, United States, 46202
United States, Iowa
University of Iowa
Recruiting
Iowa City, Iowa, United States, 52242
Contact: Edward F. Bell, MD
Principal Investigator: Edward F. Bell, MD
United States, Michigan
Wayne State University
Active, not recruiting
Detroit, Michigan, United States, 48201
United States, Missouri
Children's Mercy Hospital
Active, not recruiting
Kansas City, Missouri, United States, 64108
United States, New Mexico
University of New Mexico
Recruiting
Albuquerque, New Mexico, United States, 87131
Contact: Kristi L. Watterberg, MD
Principal Investigator: Kristi L. Watterberg, MD
United States, New York
University of Rochester
Recruiting
Rochester, New York, United States, 14642
Contact: Carl T D'Angio, MD
Principal Investigator: Carl T D'Angio, MD
United States, North Carolina
RTI International
Active, not recruiting
Durham, North Carolina, United States, 27705
Duke University
Recruiting
Durham, North Carolina, United States, 27710
Contact: C. Michael Cotten, MD
Sub-Investigator: C. Michael Cotten, MD MHS
United States, Ohio
Cincinnati Children's Medical Center
Recruiting
Cincinnati, Ohio, United States, 45267
Contact: Brenda Poindiexter, MD
Principal Investigator: Brenda Poindexter, MD
Case Western Reserve University, Rainbow Babies and Children's Hospital
Recruiting
Cleveland, Ohio, United States, 44106
Contact: Michele C. Walsh, MD MS
Principal Investigator: Michele C. Walsh, MD MS
Research Institute at Nationwide Children's Hospital
Recruiting
Columbus, Ohio, United States, 43205
Contact: Pablo Sanchez, MD
Principal Investigator: Pablo Sanchez, MD
United States, Pennsylvania
Univeristy of Pennsylvania
Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Eric Eichenwald, MD
Principal Investigator: Eric Eicenwald, MD
United States, Rhode Island
Brown University, Women & Infants Hospital of Rhode Island
Recruiting
Providence, Rhode Island, United States, 02905
Contact: Abbot R. Laptook, MD
Principal Investigator: Abbot R. Laptook, MD
United States, Texas
University of Texas Southwestern Medical Center at Dallas
Recruiting
Dallas, Texas, United States, 75235
Contact: Myra Wyckoff, MD
Principal Investigator: Myra Wyckoff, MD
University of Texas Health Science Center at Houston
Recruiting
Houston, Texas, United States, 77030
Contact: Jon E Tyson, MD MPH
Principal Investigator: Jon E. Tyson, MD MPH
United States, Utah
University of Utah
Recruiting
Salt Lake City, Utah, United States, 84108
Contact: Bradley Yoder, MD
Principal Investigator: Bradley A. Yoder, MD 收起 <<
United States, Alabama
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University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233
United States, California
University of California - Los Angeles
Los Angeles, California, United States, 90025
Stanford University
Palo Alto, California, United States, 94304
United States, Georgia
Emory University
Atlanta, Georgia, United States, 30303
United States, Indiana
Indiana University
Indianapolis, Indiana, United States, 46202
United States, Iowa
University of Iowa
Iowa City, Iowa, United States, 52242
United States, Michigan
Wayne State University
Detroit, Michigan, United States, 48201
United States, Missouri
Children's Mercy Hospital
Kansas City, Missouri, United States, 64108
United States, New Mexico
University of New Mexico
Albuquerque, New Mexico, United States, 87131
United States, New York
University of Rochester
Rochester, New York, United States, 14642
United States, North Carolina
RTI International
Durham, North Carolina, United States, 27705
Duke University
Durham, North Carolina, United States, 27710
United States, Ohio
Cincinnati Children's Medical Center
Cincinnati, Ohio, United States, 45267
Case Western Reserve University
Cleveland, Ohio, United States, 44106
Research Institute at Nationwide Children's Hospital
Columbus, Ohio, United States, 43205
United States, Pennsylvania
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
United States, Texas
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, United States, 75235
University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030 收起 <<
Australia, South Australia
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CMAX A division of IDT Australia Limited
Adelaide, South Australia, Australia, 5000
Hong Kong
The University of Hong Kong; Pharmacy Clinical Trials
Hong Kong, Hong Kong
The Chinese University of Hong Kong; Emergency Medicine
Shatin, Hong Kong, 00000
New Zealand
Christchurch Clinical Studies Trust
Christchurch, New Zealand, 8011
Auckland Clinical Studies Limited
Grafton, New Zealand, 1010
Singapore
SingHealth Investigational Medicine Unit; Haematology
Singapore, Singapore, 169608
Changi General Hospital- Parent; Department of Rheumatology
Singapore, Singapore, 529889
Taiwan
China Medical University Hospital;Oncology and Hematology Office Critical Care Center, 14H
Taichung, Taiwan, 404
Taipei Medical University Hospital; Clinical Research Center
Taipei City, Taiwan, 110 收起 <<
United States, California
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Elk Grove Clinical Research
Elk Grove, California, United States, 95758
United States, Florida
The Chappel Group Research
Kissimmee, Florida, United States, 34744
San Marcus Research
Miami, Florida, United States, 33015
L&C Professional Medical Research Institute
Miami, Florida, United States, 33144
LSRN Research
West Palm Beach, Florida, United States, 33407
United States, Washington
Mid Columbia Research
Richland, Washington, United States, 99352 收起 <<
United States, California
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Axis Clinical Trials
Los Angeles, California, United States, 90017
Axis Clinical Trials
Los Angeles, California, United States, 90036
United States, Florida
South Florida Family Health and Research Centers (Lice Source Services Inc)
Miami, Florida, United States, 33186
South Florida Family Health and Research Centers (Lice Source Services Inc)
Plantation, Florida, United States, 33313 收起 <<
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