Benproperine Phosphate is an ARPC2 (Actin-related protein 2/3 complex subunit 2) inhibitor which works as an inhibitor of cancer cell migration and an anti-metastatic agent.
Benproperine is an ARPC2 (Actin-related protein 2/3 complex subunit 2) inhibitor which works as an inhibitor of cancer cell migration and an anti-metastatic agent. Benproperine could bound directly to ARPC2 in cells and inhibit Arp2/3 function by displaying disruption of lamellipodial structure and inhibition of actin polymerization. Unlike Arp2/3 inhibitors, Benproperine selectively inhibited the migration of cancer cells but not normal cells. Benproperine significantly inhibited the migration, but not viability, of various types of cancer cells with IC50 values of 1-2 mM for DLD-1 and AsPC-1 cells. Oral administration of 50mg/kg Benproperine 5 days per week for 4 weeks strongly suppressed lung metastasis of AsPC-1 cells (56.1% inhibition) and metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%.
作用机制
Benproperine can directly bind to ARPC2 and inhibit cancer cell migration through Arp2/3.[1]
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