Benproperine phosphate
产品说明书
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同义名 : | BPP;ASA 158-5;Benproperine (phosphate);Pirexyl phosphate;Blascorid |
| CAS号 : | 19428-14-9 | |
| 货号 : | A812896 | |
| 分子式 : | C21H30NO5P | |
| 纯度 : | 99+% | |
| 分子量 : | 407.44 | |
| MDL号 : | MFCD01700461 | |
| 存储条件： |
Pure form Inert atmosphere,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(294.52 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(245.43 mM) |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Benproperine is an ARPC2 (Actin-related protein 2/3 complex subunit 2) inhibitor which works as an inhibitor of cancer cell migration and an anti-metastatic agent. Benproperine could bound directly to ARPC2 in cells and inhibit Arp2/3 function by displaying disruption of lamellipodial structure and inhibition of actin polymerization. Unlike Arp2/3 inhibitors, Benproperine selectively inhibited the migration of cancer cells but not normal cells. Benproperine significantly inhibited the migration, but not viability, of various types of cancer cells with IC50 values of 1-2 mM for DLD-1 and AsPC-1 cells. Oral administration of 50mg/kg Benproperine 5 days per week for 4 weeks strongly suppressed lung metastasis of AsPC-1 cells (56.1% inhibition) and metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%. | ||
| 作用机制 | Benproperine can directly bind to ARPC2 and inhibit cancer cell migration through Arp2/3.[1] | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.23mL 0.65mL 0.32mL |
16.16mL 3.23mL 1.62mL |
32.32mL 6.46mL 3.23mL |
| 参考文献 |
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