产品说明书

Bendamustine

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Chemical Structure| 16506-27-7 同义名 : SDX-105 free base
CAS号 : 16506-27-7
货号 : A539745
分子式 : C16H21Cl2N3O2
纯度 : 98+%
分子量 : 358.263
MDL号 : MFCD00866481
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(293.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • DNA synthesis
描述 Bendamustine (SDX-105 free base), a purine analogue, acts as a DNA cross-linking agent, activating DNA-damage stress response and apoptosis. It possesses potent alkylating, anticancer, and antimetabolite properties [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.79mL

0.56mL

0.28mL

13.96mL

2.79mL

1.40mL

27.91mL

5.58mL

2.79mL
参考文献

[1]Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17.

[2]Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17.

[3]Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167(4):881-91.