吲哚美辛吗啉代酰胺 /BML-190
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货号：A909570
同义名：
Indomethacin morpholinylamide;IMMA
BML-190 is a selective cannabinoid CB2 receptor inverse agonist with Ki of 435 nM, with 50-fold selectivity over CB1 receptor.
BML-190 化学结构
BML-190 3D分子结构
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BML-190 纯度/质量文件 产品仅供科研
货号：A909570
标准纯度：
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产品说明书
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BML-190 质控信息
Otenabant HCl
++++
rCB1, Ki: 2.8 nM
hCB1, Ki: 0.7 nM
98+%
AM251
✔
98%
Rimonabant
+++
++
98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
BML-190 生物活性
描述
BML-190, a known inverse agonist of mammalian cannabinoid receptors. BML-190 likely targets the C. neoformans G-protein-coupled receptor Gpr4 and, via the cyclic AMP (cAMP)/protein kinase A (PKA) signaling pathway, contributes to an intracellular accumulation of cAMP that results in decreased chitosan[3] [4] [5]
BML-190 参考文献
[1] Zhang Q, Ma P, et al. In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB(2)) in rat liver microsomes. Eur J Pharm Sci. 2010 Sep 11;41(1):163-72.
[2] New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Lett. 2003 Feb 11;536(1-3):157-60.
[3] Maybruck BT, Lam WC, Specht CA, Ilagan MXG, Donlin MJ, Lodge JK. The Aminoalkylindole BML-190 Negatively Regulates Chitosan Synthesis via the Cyclic AMP/Protein Kinase A1 Pathway in Cryptococcus neoformans. mBio. 2019;10(6):e02264-19. Published 2019 Dec 17
[4] New DC, Wong YH. BML-190 and AM251 act as inverse agonists at the human cannabinoid CB2 receptor: signalling via cAMP and inositol phosphates. FEBS Lett. 2003;536(1-3):157-160
[5] Klegeris A, Bissonnette CJ, McGeer PL. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. Br J Pharmacol. 2003;139(4):775-786
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BML-190 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.34mL
0.47mL
0.23mL
11.71mL
2.34mL
1.17mL
23.43mL
4.69mL
2.34mL
BML-190 技术信息
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