货号:A1210118 同义名: Aurora Kinase Inhibitor II;4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline
Aurora kinase inhibitor-2是一种 Aurora 激酶抑制剂,通过干扰 Aurora 激酶的活性,阻断细胞周期进程,具有抗癌潜力,特别是在乳腺癌和卵巢癌研究中。
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产品名称 | Aurora A ↓ ↑ | Aurora B ↓ ↑ | Aurora C ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BI-847325 |
++
Aurora A (Human), IC50: 25 nM |
++++
Aurora B (Xenopus laevis), IC50: 3 nM |
++
Aurora C (Human), IC50: 15 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
CCT 137690 |
++
Aurora A, IC50: 15 nM |
++
Aurora B, IC50: 25 nM |
++
Aurora C, IC50: 19 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
MK-5108 |
++++
Aurora A, IC50: 0.064 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
KW-2449 |
+
Aurora A, IC50: 48 nM |
FLT3 | {[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Tozasertib |
++++
Aurora A, Ki app: 0.6 nM |
++
Aurora B, Ki app: 18 nM |
+++
Aurora C, Ki app: 4.6 nM |
FLT3,Bcr-Abl | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
AT9283 |
++++
Aurora A, IC50: ~3.0 nM |
++++
Aurora B, IC50: ~3.0 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
MLN8054 |
+++
Aurora A, IC50: 4 nM |
+
Aurora B, IC50: 172 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
ZM-447439 |
+
Aurora A, IC50: 110 nM |
+
Aurora B, IC50: 130 nM |
Src | {[allProObj[0].p_purity_real_show]} | |||||||||||||||
TCS7010 |
++++
Aurora A, IC50: 3.4 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
TAK-901 |
++
Aurora A-TPX2, IC50: 21 nM |
++
Aurora B-INCENP, IC50: 15 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
Danusertib |
+++
Aurora A, IC50: 13 nM |
+
Aurora B, IC50: 79 nM |
+
Aurora C, IC50: 61 nM |
RET | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
MK-8745 |
++++
Aurora A, IC50: 0.6 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
PHA-680632 |
++
Aurora A, IC50: 27 nM |
+
Aurora B, IC50: 135 nM |
+
Aurora C, IC50: 120 nM |
FLT3 | {[allProObj[0].p_purity_real_show]} | ||||||||||||||
AMG 900 |
+++
Aurora A, IC50: 5 nM |
+++
Aurora B, IC50: 4 nM |
++++
Aurora C, IC50: 1 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
Alisertib |
++++
Aurora A, IC50: 1.2 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
ENMD-2076 |
+++
Aurora A, IC50: 14 nM |
+
Aurora B, IC50: 350 nM |
FLT3,RET | {[allProObj[0].p_purity_real_show]} | |||||||||||||||
JNJ-7706621 |
+++
Aurora A, IC50: 11 nM |
++
Aurora B, IC50: 15 nM |
{[allProObj[0].p_purity_real_show]} | ||||||||||||||||
CYC-116 |
+++
Aurora A, Ki: 8 nM |
+++
Aurora B, Ki: 9 nM |
FLT3 | {[allProObj[0].p_purity_real_show]} | |||||||||||||||
Reversine |
+++
Aurora A, IC50: 12 nM |
+++
Aurora B, IC50: 13 nM |
++
Aurora C, IC50: 20 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
CCT129202 |
++
Aurora A, IC50: 42 nM |
+
Aurora B, IC50: 198 nM |
+
Aurora C, IC50: 227 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
SNS-314 mesylate |
+++
Aurora A, IC50: 9 nM |
++
Aurora B, IC50: 31 nM |
++++
Aurora C, IC50: 3 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||
Barasertib-HQPA |
++++
Aurora B, IC50: 0.37 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Hesperadin |
+
Aurora B (human), IC50: 250 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
GSK-1070916 |
++++
Aurora B-INCENP, IC50: 3.5 nM |
+++
Aurora C-INCENP, IC50: 6.5 nM |
Tie-2,SIK | {[allProObj[0].p_purity_real_show]} | |||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Aurora kinase inhibitor-2 is a selective, ATP-competitive inhibitor of Aurora kinase, with IC50 values of 310 nM for Aurora kinase A and 240 nM for Aurora kinase B. Aurora kinase inhibitor-2 has been shown to be effective in an antiproliferative assay on MCF7 cells (IC50 value of 1.25 µM)[1]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.50mL 0.50mL 0.25mL |
12.49mL 2.50mL 1.25mL |
24.97mL 4.99mL 2.50mL |
CAS号 | 331770-21-9 |
分子式 | C23H20N4O3 |
分子量 | 400.43 |
别名 | Aurora Kinase Inhibitor II;4-(4ʹ-Benzamidoanilino)-6,7-dimethoxyquinazoline;IUN-70219 |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(262.22 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |